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    SPHK1 sphingosine kinase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 483329, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SPHK1provided by VGNC
    Official Full Name
    sphingosine kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:49655
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SPHK1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (4984498..4988116, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (4992955..4996576, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (5213806..5217418, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (5012727..5016344, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (5132520..5136143, complement)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097290 Neighboring gene ubiquitin conjugating enzyme E2 O Neighboring gene uncharacterized LOC106559235 Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection. Seo YJ, et al. PLoS One, 2013. PMID 24137500, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SK is a key pro-viral factor regulating multiple cellular signal pathways triggered by influenza virus infection
      Title: Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables D-erythro-sphingosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sphingosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphingosine kinase 1
    XP_038343483.1
    XP_038405414.1
    XP_038469344.1
    XP_038477950.1
    XP_038531200.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      4984498..4988116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038675272.1 → XP_038531200.1  sphingosine kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I3S0D0
      Conserved Domains (2) summary
      PLN02958
      Location:221 → 558
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
      PHA03247
      Location:8 → 144
      PHA03247; large tegument protein UL36; Provisional

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      5012727..5016344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038487555.1 → XP_038343483.1  sphingosine kinase 1 isoform X2

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      5132520..5136143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038613416.1 → XP_038469344.1  sphingosine kinase 1 isoform X1

      Conserved Domains (2) summary
      PLN02958
      Location:221 → 558
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
      PHA03247
      Location:8 → 144
      PHA03247; large tegument protein UL36; Provisional

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      5213806..5217418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038549486.1 → XP_038405414.1  sphingosine kinase 1 isoform X3

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      4992955..4996576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038622022.1 → XP_038477950.1  sphingosine kinase 1 isoform X4

      Conserved Domains (2) summary
      PLN02958
      Location:242 → 579
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
      PRK07003
      Location:8 → 243
      PRK07003; DNA polymerase III subunit gamma/tau
    Nucleotide Protein
    Heading Accession and Version

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