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    ZYX zyxin [ Canis lupus familiaris (dog) ]

    Gene ID: 482736, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ZYXprovided by VGNC
    Official Full Name
    zyxinprovided by VGNC
    Primary source
    VGNC:VGNC:51838
    See related
    Ensembl:ENSCAFG00845016481
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See ZYX in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (6157384..6166501, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (7292681..7301847, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (6032095..6041208, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (6105301..6114400, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (5956860..5966008, complement)

    Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102155484 Neighboring gene EPH receptor A1 Neighboring gene family with sequence similarity 131 member B Neighboring gene chloride voltage-gated channel 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VASP, zyxin and TES are tension-dependent members of focal adherens junctions independent of the alpha-catenin-vinculin module.
      Title: VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module.
    2. Data show that in zyxin-deficient cells, the actin assembly at both focal adhesion and cell-cell adhesion was limited, but their migration rate was unchanged.
      Title: Zyxin-mediated actin assembly is required for efficient wound closure.
    3. Zyxin controls migration in epithelial-mesenchymal transition by mediating actin-membrane linkages at cell-cell junctions.
      Title: Zyxin controls migration in epithelial-mesenchymal transition by mediating actin-membrane linkages at cell-cell junctions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zyxin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051820.1 Reference ROS_Cfam_1.0

      Range
      6157384..6166501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038689008.1 → XP_038544936.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8C0N7N3
      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038689006.1 → XP_038544934.1  zyxin isoform X1

      UniProtKB/TrEMBL
      A0A8C0N7N3, A0A8C0Q872, A0A8C0R4U8, A0A8I3NVB0
      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_038689009.1 → XP_038544937.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8C0N7N3
      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_038689007.1 → XP_038544935.1  zyxin isoform X1

      UniProtKB/TrEMBL
      A0A8C0N7N3, A0A8C0Q872, A0A8C0R4U8, A0A8I3NVB0
      Related
      ENSCAFP00845023059.1, ENSCAFT00845029329.1
      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049276.1 Alternate UMICH_Zoey_3.1

      Range
      6105301..6114400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038496961.1 → XP_038352889.1  zyxin isoform X2

      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038496959.1 → XP_038352887.1  zyxin isoform X1

      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_038496962.1 → XP_038352890.1  zyxin isoform X2

      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_038496960.1 → XP_038352888.1  zyxin isoform X1

      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

      Range
      5956860..5966008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038623276.1 → XP_038479204.1  zyxin isoform X2

      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038623273.1 → XP_038479201.1  zyxin isoform X1

      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_038623277.1 → XP_038479205.1  zyxin isoform X2

      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_038623274.1 → XP_038479202.1  zyxin isoform X1

      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

      Range
      6032095..6041208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038559294.1 → XP_038415222.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8C0N7N3
      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038559292.1 → XP_038415220.1  zyxin isoform X1

      UniProtKB/TrEMBL
      A0A8C0N7N3, A0A8C0Q872, A0A8C0R4U8, A0A8I3NVB0
      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_038559295.1 → XP_038415223.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8C0N7N3
      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_038559293.1 → XP_038415221.1  zyxin isoform X1

      UniProtKB/TrEMBL
      A0A8C0N7N3, A0A8C0Q872, A0A8C0R4U8, A0A8I3NVB0
      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      7292681..7301847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038452461.1 → XP_038308389.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8C0N7N3
      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038452459.1 → XP_038308387.1  zyxin isoform X1

      UniProtKB/TrEMBL
      A0A8C0N7N3, A0A8C0Q872, A0A8C0R4U8, A0A8I3NVB0
      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_038452462.1 → XP_038308390.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8C0N7N3
      Conserved Domains (4) summary
      cd09353
      Location:411 → 470
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:471 → 537
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:3 → 317
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:318 → 404
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_038452460.1 → XP_038308388.1  zyxin isoform X1

      UniProtKB/TrEMBL
      A0A8C0N7N3, A0A8C0Q872, A0A8C0R4U8, A0A8I3NVB0
      Conserved Domains (4) summary
      cd09353
      Location:442 → 501
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:502 → 568
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:164 → 348
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:349 → 435
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein
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