PODXL podocalyxin like [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PODXLprovided by VGNC
Official Full Name: podocalyxin likeprovided by VGNC
Primary source: VGNC:VGNC:54792
See related: Ensembl:ENSCAFG00845015545
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: PC; PCLP; Gp135; PCLP1; PCLP-1; cPCLP1
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	14	NC_051818.1 (5352258..5363616)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	14	NC_006596.4 (5275959..5287312)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	14	NC_049235.1 (5404060..5454526)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	14	NC_049274.1 (5516244..5566654)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	14	NC_049755.1 (5261499..5311827)

Chromosome 14 - NC_051818.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results reveal a new role of Gal-8 in the development of luminal organs by regulating targeting of apical polarity protein Gp135
Title: Galectin-8 regulates targeting of Gp135/podocalyxin and lumen formation at the apical surface of renal epithelial cells.
correct apical sorting of podocalyxin depends on a bipartite signal composed of an extracellular O-glycosylation-rich region and the intracellular PDZ domain-binding motif
Title: A bipartite signal regulates the faithful delivery of apical domain marker podocalyxin/Gp135.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell-cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of microvillus assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: podocalyxin

Names: PC-like protein 1; Podocalyxin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.