TG thyroglobulin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: TGprovided by VGNC
Official Full Name: thyroglobulinprovided by VGNC
Primary source: VGNC:VGNC:47306
See related: Ensembl:ENSCAFG00845008772
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	13	NC_051817.1 (29705326..29954007)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	13	NC_006595.4 (29323440..29571872)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	13	NC_049234.1 (29844402..30129590)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	13	NC_049273.1 (29431959..29680604)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	13	NC_049754.1 (29532359..29781038)

Chromosome 13 - NC_051817.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thyroglobulin as a negative marker for malignancy in canine and human breast tumors.
Title: Thyroglobulin as a negative marker for malignancy in canine and human breast tumors.
To identify canine-specific areas in Tg, the complete cDNA of Tg was studied, it has an open reading frame of 8289 nucleotides, which encode a polypeptide of 2762 amino acids that is 78.9 and 78.1% identical to bovine and human tg, respectively.
Title: Cloning and characterization of canine thyroglobulin complementary DNA.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in thyroid hormone generation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: thyroglobulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048104.1 → NP_001041569.1 thyroglobulin precursor

See identical proteins and their annotated locations for NP_001041569.1

Status: PROVISIONAL

Source sequence(s)

AB231914

UniProtKB/TrEMBL

A0A8I3RWH6, Q1ERT3

Related

ENSCAFP00845012357.1, ENSCAFT00845015882.1

Conserved Domains (6) summary

smart00211
Location:1521 → 1566

TY; Thyroglobulin type I repeats

cd00191
Location:95 → 160

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam00086
Location:660 → 724

Thyroglobulin_1; Thyroglobulin type-1 repeat

pfam00135
Location:2204 → 2718

COesterase; Carboxylesterase family

pfam07699
Location:1466 → 1511

GCC2_GCC3; GCC2 and GCC3

cl00150
Location:727 → 774

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051817.1 Reference ROS_Cfam_1.0

Range

29705326..29954007

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038684537.1 → XP_038540465.1 thyroglobulin isoform X1

UniProtKB/TrEMBL

A0A8I3RWH6

Conserved Domains (6) summary

smart00211
Location:885 → 921

TY; Thyroglobulin type I repeats

cd00191
Location:95 → 160

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam00086
Location:660 → 722

Thyroglobulin_1; Thyroglobulin type-1 repeat

pfam00135
Location:2140 → 2661

COesterase; Carboxylesterase family

pfam07699
Location:1466 → 1510

Ephrin_rec_like; Putative ephrin-receptor like

cl00150
Location:727 → 774

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases