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    SIM1 SIM bHLH transcription factor 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 481937, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SIM1provided by VGNC
    Official Full Name
    SIM bHLH transcription factor 1provided by VGNC
    Primary source
    VGNC:VGNC:46174
    See related
    Ensembl:ENSCAFG00845005849
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SIM1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (59313324..59386528, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (58239464..58312667, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (58747572..58820839, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (58666215..58739215, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (58507210..58580362, complement)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111098371 Neighboring gene uncharacterized LOC102153675 Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene uncharacterized LOC119874223 Neighboring gene activating signal cointegrator 1 complex subunit 3 Neighboring gene sorcin-like Neighboring gene small nucleolar RNA SNORA38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide identification and analysis of basic helix-loop-helix domains in dog, Canis lupus familiaris. Wang XH, et al. Mol Genet Genomics, 2015 Apr. PMID 25403511
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    single-minded homolog 1
    Names
    single-minded family bHLH transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      59313324..59386528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038684239.1 → XP_038540167.1  single-minded homolog 1

      UniProtKB/TrEMBL
      A0A8C0KX91, A0A8C0NDN0, A0A8C0Q6A7, A0A8I3MZE5
      Related
      ENSCAFP00845008056.1, ENSCAFT00845010363.1
      Conserved Domains (4) summary
      cd00130
      Location:88 → 158
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:243 → 329
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
      pfam06621
      Location:360 → 669
      SIM_C; Single-minded protein C-terminus

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      58666215..58739215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038492499.1 → XP_038348427.1  single-minded homolog 1

      Conserved Domains (4) summary
      cd00130
      Location:88 → 158
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:243 → 329
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
      pfam06621
      Location:360 → 669
      SIM_C; Single-minded protein C-terminus

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      58507210..58580362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038618680.1 → XP_038474608.1  single-minded homolog 1

      Conserved Domains (4) summary
      cd00130
      Location:88 → 158
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:243 → 329
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
      pfam06621
      Location:360 → 669
      SIM_C; Single-minded protein C-terminus

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      58747572..58820839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038554802.1 → XP_038410730.1  single-minded homolog 1

      UniProtKB/TrEMBL
      A0A8C0KX91, A0A8C0NDN0, A0A8C0Q6A7, A0A8I3MZE5
      Conserved Domains (4) summary
      cd00130
      Location:88 → 158
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:243 → 329
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
      pfam06621
      Location:360 → 669
      SIM_C; Single-minded protein C-terminus

    2. XM_038554803.1 → XP_038410731.1  single-minded homolog 1

      UniProtKB/TrEMBL
      A0A8C0KX91, A0A8C0NDN0, A0A8C0Q6A7, A0A8I3MZE5
      Conserved Domains (4) summary
      cd00130
      Location:88 → 158
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:243 → 329
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
      pfam06621
      Location:360 → 669
      SIM_C; Single-minded protein C-terminus

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      58239464..58312667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_539058.6 → XP_539058.2  single-minded homolog 1

      UniProtKB/TrEMBL
      A0A8C0KX91, A0A8C0NDN0, A0A8C0Q6A7, A0A8I3MZE5
      Conserved Domains (4) summary
      cd00130
      Location:88 → 158
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:243 → 329
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
      pfam06621
      Location:360 → 669
      SIM_C; Single-minded protein C-terminus
    Nucleotide Protein
    Heading Accession and Version

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