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    LOC481709 POU domain, class 5, transcription factor 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 481709, updated on 22-Jan-2024

    Summary

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    Gene symbol
    LOC481709
    Gene description
    POU domain, class 5, transcription factor 1
    See related
    Ensembl:ENSCAFG00845017478
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    OCT4
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    Genomic context

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    See LOC481709 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (86365..91333)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (998319..1003284, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (1000755..1005716, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (864674..869639, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (932964..937930, complement)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102152528 Neighboring gene uncharacterized LOC119874136 Neighboring gene transcription factor 19 Neighboring gene coiled-coil alpha-helical rod protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours. Vargas TH, et al. J Comp Pathol, 2015 Nov. PMID 26460092
    2. Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasia. Webster JD, et al. Vet Pathol, 2007 Nov. PMID 18039902
    3. Domestic carnivore's development: detection of Oct-4, a pluripotency marker, in pharyngeal arches. Roballo KC, et al. Reprod Domest Anim, 2013 Jun. PMID 23379423
    4. Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair. Erwin WM, et al. Spine (Phila Pa 1976), 2013 Feb 1. PMID 22772571

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. suggest that OCT4 expression is not a precise prognostic indicator for canine mast cell tumour
      Title: Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours.
    2. The expression of Oct4 in the pharyngeal arches of dog and cat embryos aged 17-25 days is reported.
      Title: Domestic carnivore's development: detection of Oct-4, a pluripotency marker, in pharyngeal arches.
    3. Data indicate that intervertebral disc (IVD)-derived stem/progenitor cells express Oct3/4, Sox2, CD133 (PROM1), Nanog, and Nestin.
      Title: Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair.
    4. This study evaluated the hypothesis that octamer transcription factor 4 (Oct4)-positive cells are present in all canine neoplasms and that these subpopulations of neoplastic cells might represent "cancer stem" cells.
      Title: Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasia.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    POU domain, class 5, transcription factor 1; LOW QUALITY PROTEIN: POU domain, class 5, transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      86365..91333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038682857.1 → XP_038538785.1  LOW QUALITY PROTEIN: POU domain, class 5, transcription factor 1

      UniProtKB/TrEMBL
      A0A8I3PB46
      Related
      ENSCAFP00845024367.1, ENSCAFT00845031112.1
      Conserved Domains (2) summary
      smart00352
      Location:138 → 212
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:233 → 287
      Homeobox; Homeobox domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      864674..869639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038492747.1 → XP_038348675.1  LOW QUALITY PROTEIN: POU domain, class 5, transcription factor 1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      932964..937930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038617209.1 → XP_038473137.1  POU domain, class 5, transcription factor 1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      1000755..1005716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038553312.1 → XP_038409240.1  POU domain, class 5, transcription factor 1

      UniProtKB/TrEMBL
      A0A8C0L622, A0A8C0MBD5, A0A8I3PB46, A0A8P0N3Q7

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      998319..1003284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_538830.4 → XP_538830.1  POU domain, class 5, transcription factor 1

      UniProtKB/TrEMBL
      A0A8C0L622, A0A8C0MBD5, A0A8I3PB46, A0A8P0N3Q7
      Conserved Domains (2) summary
      smart00352
      Location:138 → 212
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:233 → 286
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials