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    RANGAP1 Ran GTPase activating protein 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 481234, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RANGAP1provided by VGNC
    Official Full Name
    Ran GTPase activating protein 1provided by VGNC
    Primary source
    VGNC:VGNC:45340
    See related
    Ensembl:ENSCAFG00845017556
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See RANGAP1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (24698293..24730051)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (23886012..23917770)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (24910123..24941882)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (24414746..24446498)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (24735632..24767361)

    Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene TEF transcription factor, PAR bZIP family member Neighboring gene zinc finger CCCH-type containing 7B Neighboring gene chondroadherin like Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene uncharacterized LOC102155369 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly of the β4-Integrin Interactome Based on Proximal Biotinylation in the Presence and Absence of Heterodimerization. Myllymäki SM, et al. Mol Cell Proteomics, 2019 Feb. PMID 30404858, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ran GTPase-activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051814.1 Reference ROS_Cfam_1.0

      Range
      24698293..24730051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038679745.1 → XP_038535673.1  ran GTPase-activating protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JKM9, A0A8C0P8X1, A0A8C0T0E8, A0A8I3P4H2
      Related
      ENSCAFP00845024655.1, ENSCAFT00845031485.1
      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    2. XM_038679746.1 → XP_038535674.1  ran GTPase-activating protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JKM9, A0A8C0P8X1, A0A8C0T0E8, A0A8I3P4H2
      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    3. XM_038679744.1 → XP_038535672.1  ran GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0P8X1
      Conserved Domains (3) summary
      cd00116
      Location:62 → 399
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:92 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:446 → 626
      RanGAP1_C; RanGAP1 C-terminal domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049270.1 Alternate UMICH_Zoey_3.1

      Range
      24414746..24446498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038488509.1 → XP_038344437.1  ran GTPase-activating protein 1 isoform X2

      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    2. XM_038488510.1 → XP_038344438.1  ran GTPase-activating protein 1 isoform X2

      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    3. XM_038488508.1 → XP_038344436.1  ran GTPase-activating protein 1 isoform X1

      Conserved Domains (3) summary
      cd00116
      Location:62 → 399
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:92 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:446 → 626
      RanGAP1_C; RanGAP1 C-terminal domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

      Range
      24735632..24767361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038614404.1 → XP_038470332.1  ran GTPase-activating protein 1 isoform X2

      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    2. XM_038614402.1 → XP_038470330.1  ran GTPase-activating protein 1 isoform X3

    3. XM_038614403.1 → XP_038470331.1  ran GTPase-activating protein 1 isoform X2

      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

      Range
      24910123..24941882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038550437.1 → XP_038406365.1  ran GTPase-activating protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JKM9, A0A8C0P8X1, A0A8C0T0E8, A0A8I3P4H2
      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    2. XM_038550438.1 → XP_038406366.1  ran GTPase-activating protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JKM9, A0A8C0P8X1, A0A8C0T0E8, A0A8I3P4H2
      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    3. XM_038550436.1 → XP_038406364.1  ran GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0P8X1
      Conserved Domains (3) summary
      cd00116
      Location:62 → 399
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:92 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:446 → 626
      RanGAP1_C; RanGAP1 C-terminal domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23886012..23917770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_538355.7 → XP_538355.3  ran GTPase-activating protein 1 isoform X2

      See identical proteins and their annotated locations for XP_538355.3

      UniProtKB/TrEMBL
      A0A8C0JKM9, A0A8C0P8X1, A0A8C0T0E8, A0A8I3P4H2
      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    2. XM_005625833.4 → XP_005625890.1  ran GTPase-activating protein 1 isoform X2

      See identical proteins and their annotated locations for XP_005625890.1

      UniProtKB/TrEMBL
      A0A8C0JKM9, A0A8C0P8X1, A0A8C0T0E8, A0A8I3P4H2
      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 585
      RanGAP1_C; RanGAP1 C-terminal domain

    3. XM_005625832.4 → XP_005625889.1  ran GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0P8X1
      Conserved Domains (3) summary
      cd00116
      Location:62 → 399
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:92 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:446 → 626
      RanGAP1_C; RanGAP1 C-terminal domain
    Nucleotide Protein
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