U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    STAT2 signal transducer and activator of transcription 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 481111, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    STAT2provided by VGNC
    Official Full Name
    signal transducer and activator of transcription 2provided by VGNC
    Primary source
    VGNC:VGNC:108218
    See related
    Ensembl:ENSCAFG00845008098
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See STAT2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (650365..669707, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (704962..724101, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (994493..1013823, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (627617..646943, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (870771..890099, complement)

    Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111089980 Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene interleukin 23 subunit alpha Neighboring gene 60S ribosomal protein L6-like Neighboring gene apolipoprotein F Neighboring gene timeless circadian regulator

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    signal transducer and activator of transcription 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051814.1 Reference ROS_Cfam_1.0

      Range
      650365..669707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038679015.1 → XP_038534943.1  signal transducer and activator of transcription 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0LLW2, A0A8I3N7X7
      Conserved Domains (5) summary
      cd10373
      Location:549 → 699
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:310 → 468
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 306
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:783 → 835
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    2. XM_038679013.1 → XP_038534941.1  signal transducer and activator of transcription 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW2, A0A8I3N2N6, A0A8I3N7X7
      Related
      ENSCAFP00845011091.1, ENSCAFT00845014314.1
      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    3. XM_038679014.1 → XP_038534942.1  signal transducer and activator of transcription 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW2, A0A8I3N2N6, A0A8I3N7X7
      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    4. XM_038679016.1 → XP_038534944.1  signal transducer and activator of transcription 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QAL2
      Conserved Domains (4) summary
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      cl15255
      Location:555 → 680
      SH2; Src homology 2 (SH2) domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049270.1 Alternate UMICH_Zoey_3.1

      Range
      627617..646943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038487796.1 → XP_038343724.1  signal transducer and activator of transcription 2 isoform X2

      Conserved Domains (5) summary
      cd10373
      Location:549 → 699
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:310 → 468
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 306
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:783 → 835
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    2. XM_038487794.1 → XP_038343722.1  signal transducer and activator of transcription 2 isoform X1

      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    3. XM_038487795.1 → XP_038343723.1  signal transducer and activator of transcription 2 isoform X1

      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    4. XM_038487797.1 → XP_038343725.1  signal transducer and activator of transcription 2 isoform X3

      Conserved Domains (4) summary
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      cl15255
      Location:555 → 680
      SH2; Src homology 2 (SH2) domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

      Range
      870771..890099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038613650.1 → XP_038469578.1  signal transducer and activator of transcription 2 isoform X2

      Conserved Domains (5) summary
      cd10373
      Location:549 → 699
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:310 → 468
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 306
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:783 → 835
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    2. XM_038613648.1 → XP_038469576.1  signal transducer and activator of transcription 2 isoform X1

      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    3. XM_038613649.1 → XP_038469577.1  signal transducer and activator of transcription 2 isoform X1

      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    4. XM_038613651.1 → XP_038469579.1  signal transducer and activator of transcription 2 isoform X3

      Conserved Domains (4) summary
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      cl15255
      Location:555 → 680
      SH2; Src homology 2 (SH2) domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

      Range
      994493..1013823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038549685.1 → XP_038405613.1  signal transducer and activator of transcription 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0LLW2, A0A8I3N7X7
      Conserved Domains (5) summary
      cd10373
      Location:549 → 699
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:310 → 468
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 306
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:783 → 835
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    2. XM_038549683.1 → XP_038405611.1  signal transducer and activator of transcription 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW2, A0A8I3N2N6, A0A8I3N7X7
      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    3. XM_038549684.1 → XP_038405612.1  signal transducer and activator of transcription 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW2, A0A8I3N2N6, A0A8I3N7X7
      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    4. XM_038549686.1 → XP_038405614.1  signal transducer and activator of transcription 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QAL2
      Conserved Domains (4) summary
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      cl15255
      Location:555 → 680
      SH2; Src homology 2 (SH2) domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      704962..724101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014117155.3 → XP_013972630.2  signal transducer and activator of transcription 2 isoform X2

      UniProtKB/TrEMBL
      A0A8P0TDJ5
      Conserved Domains (5) summary
      cd10373
      Location:549 → 699
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:310 → 468
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 306
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:783 → 835
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    2. XM_538232.6 → XP_538232.3  signal transducer and activator of transcription 2 isoform X1

      UniProtKB/TrEMBL
      A0A8P0N3D7, A0A8P0TDJ5
      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    3. XM_038632890.1 → XP_038488818.1  signal transducer and activator of transcription 2 isoform X1

      UniProtKB/TrEMBL
      A0A8P0N3D7, A0A8P0TDJ5
      Conserved Domains (5) summary
      cd10373
      Location:555 → 705
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16846
      Location:316 → 474
      STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28921
      Location:141 → 312
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12188
      Location:789 → 841
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    4. XM_014117156.3 → XP_013972631.1  signal transducer and activator of transcription 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QAL2
      Conserved Domains (4) summary
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:142 → 314
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:316 → 564
      STAT_bind; STAT protein, DNA binding domain
      cl15255
      Location:555 → 680
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials