U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TSC1 TSC complex subunit 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 480688, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TSC1provided by VGNC
    Official Full Name
    TSC complex subunit 1provided by VGNC
    Primary source
    VGNC:VGNC:47890
    See related
    Ensembl:ENSCAFG00845016069
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TSC1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (52304134..52354724)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (50673940..50724548)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (51486514..51537117)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (51082516..51133112)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (51407015..51457594)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(III) chain-like Neighboring gene general transcription factor IIIC subunit 5 Neighboring gene malate dehydrogenase, mitochondrial-like Neighboring gene growth factor independent 1B transcriptional repressor Neighboring gene uncharacterized LOC119873353 Neighboring gene uncharacterized LOC111097479 Neighboring gene sperm acrosome associated 9 Neighboring gene adenylate kinase 8

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs. Jónasdóttir TJ, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10759551, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in negative regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TSC1-TSC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    hamartin
    Names
    chromosome 9 TSC1
    tuberous sclerosis 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      52304134..52354724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038678151.1 → XP_038534079.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    2. XM_038678153.1 → XP_038534081.1  hamartin isoform X2

      UniProtKB/TrEMBL
      A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:648 → 963
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 713
      Hamartin; Hamartin protein

    3. XM_038678152.1 → XP_038534080.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    4. XM_038678146.1 → XP_038534074.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Related
      ENSCAFP00845022615.1, ENSCAFT00845028734.1
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    5. XM_038678147.1 → XP_038534075.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    6. XM_038678148.1 → XP_038534076.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    7. XM_038678149.1 → XP_038534077.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      51082516..51133112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038487040.1 → XP_038342968.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    2. XM_038487042.1 → XP_038342970.1  hamartin isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:648 → 963
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 713
      Hamartin; Hamartin protein

    3. XM_038487041.1 → XP_038342969.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    4. XM_038487035.1 → XP_038342963.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    5. XM_038487036.1 → XP_038342964.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    6. XM_038487037.1 → XP_038342965.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    7. XM_038487039.1 → XP_038342967.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      51407015..51457594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038612845.1 → XP_038468773.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    2. XM_038612847.1 → XP_038468775.1  hamartin isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:648 → 963
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 713
      Hamartin; Hamartin protein

    3. XM_038612846.1 → XP_038468774.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    4. XM_038612841.1 → XP_038468769.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    5. XM_038612842.1 → XP_038468770.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    6. XM_038612843.1 → XP_038468771.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    7. XM_038612844.1 → XP_038468772.1  hamartin isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      51486514..51537117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038548894.1 → XP_038404822.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    2. XM_038548896.1 → XP_038404824.1  hamartin isoform X2

      UniProtKB/TrEMBL
      A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:648 → 963
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 713
      Hamartin; Hamartin protein

    3. XM_038548895.1 → XP_038404823.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    4. XM_038548889.1 → XP_038404817.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    5. XM_038548890.1 → XP_038404818.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    6. XM_038548892.1 → XP_038404820.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    7. XM_038548893.1 → XP_038404821.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      50673940..50724548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038616004.1 → XP_038471932.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    2. XM_022423656.2 → XP_022279364.1  hamartin isoform X2

      UniProtKB/TrEMBL
      A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:648 → 963
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 713
      Hamartin; Hamartin protein

    3. XM_038616011.1 → XP_038471939.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    4. XM_537808.7 → XP_537808.3  hamartin isoform X1

      See identical proteins and their annotated locations for XP_537808.3

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    5. XM_022423653.2 → XP_022279361.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    6. XM_022423654.2 → XP_022279362.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein

    7. XM_022423655.2 → XP_022279363.1  hamartin isoform X1

      UniProtKB/TrEMBL
      A0A8C0LLW0, A0A8C0NVV6, A0A8C0Q0D8, A0A8I3P1V6
      Conserved Domains (2) summary
      COG1196
      Location:704 → 970
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04388
      Location:7 → 718
      Hamartin; Hamartin protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials