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    MAPT microtubule associated protein tau [ Canis lupus familiaris (dog) ]

    Gene ID: 480488, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MAPTprovided by VGNC
    Official Full Name
    microtubule associated protein tauprovided by VGNC
    Primary source
    VGNC:VGNC:43012
    See related
    Ensembl:ENSCAFG00845022253
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See MAPT in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (11161388..11263326, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (10679514..10725761)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (17249716..17295984)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (10175159..10221409, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (17303033..17349281)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene microRNA mir-8885 Neighboring gene uncharacterized LOC119873239 Neighboring gene uncharacterized LOC111097312 Neighboring gene signal peptide peptidase like 2C Neighboring gene corticotropin releasing hormone receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment. Smolek T, et al. J Comp Neurol, 2016 Mar 1. PMID 26239295
    2. Cerebrospinal fluid tau protein as a biomarker for severity of spinal cord injury in dogs with intervertebral disc herniation. Roerig A, et al. Vet J, 2013 Aug. PMID 23499240
    3. Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits. Pugliese M, et al. Acta Neuropathol, 2006 Aug. PMID 16775693

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cerebrospinal fluid protein tau levels are positively associated with the severity of spinal cord damage and may serve as a prognostic indicator in dogs with intervertebral disc herniation .
      Title: Cerebrospinal fluid tau protein as a biomarker for severity of spinal cord injury in dogs with intervertebral disc herniation.
    2. Study suggests that cognitive decline in dogs is related to the tau synaptic impairment and neuroinflammation
      Title: Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
    3. results in dog suggest that beta-amyloid diffuse plaque formation and tau hyperphosphorylation are independent events, both occurring during the process of aging
      Title: Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule-associated protein tau

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110801.2 → NP_001104271.2  microtubule-associated protein tau

      Status: INFERRED

      Source sequence(s)
      JAAUVH010000313
      UniProtKB/TrEMBL
      A0A8C0MR30
      Conserved Domains (3) summary
      PHA03247
      Location:229 → 577
      PHA03247; large tegument protein UL36; Provisional
      PRK13108
      Location:51 → 182
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam00418
      Location:599 → 628
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      11161388..11263326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038675001.1 → XP_038530929.1  microtubule-associated protein tau isoform X2

      UniProtKB/TrEMBL
      A0A8I3PBQ3
      Conserved Domains (2) summary
      PHA03247
      Location:188 → 584
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:608 → 638
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    2. XM_038674998.1 → XP_038530926.1  microtubule-associated protein tau isoform X1

      UniProtKB/TrEMBL
      A0A8C0S849
      Related
      ENSCAFP00845031191.1, ENSCAFT00845039827.1
      Conserved Domains (3) summary
      PHA03247
      Location:304 → 652
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:21 → 384
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:674 → 703
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    3. XM_038674999.1 → XP_038530927.1  microtubule-associated protein tau isoform X1

      UniProtKB/TrEMBL
      A0A8C0S849
      Conserved Domains (3) summary
      PHA03247
      Location:304 → 652
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:21 → 384
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:674 → 703
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    4. XM_038675004.1 → XP_038530932.1  microtubule-associated protein tau isoform X5

      UniProtKB/TrEMBL
      A0A8I3PJH2
      Conserved Domains (2) summary
      PHA03247
      Location:69 → 377
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:400 → 429
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    5. XM_038675003.1 → XP_038530931.1  microtubule-associated protein tau isoform X4

      UniProtKB/TrEMBL
      A0A8I3PJH2
      Conserved Domains (2) summary
      PHA03247
      Location:98 → 406
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:429 → 458
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    6. XM_038675002.1 → XP_038530930.1  microtubule-associated protein tau isoform X3

      UniProtKB/TrEMBL
      A0A8I3PJH2
      Related
      ENSCAFP00845030755.1, ENSCAFT00845039265.1
      Conserved Domains (2) summary
      PHA03247
      Location:54 → 435
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:458 → 487
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    7. XM_038675006.1 → XP_038530934.1  microtubule-associated protein tau isoform X7

      UniProtKB/TrEMBL
      A0A8C0LNF2, A0A8C0S8K5, A0A8I3S5L2
      Conserved Domains (2) summary
      PHA03247
      Location:69 → 307
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:330 → 359
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    8. XM_038675005.1 → XP_038530933.1  microtubule-associated protein tau isoform X6

      UniProtKB/TrEMBL
      A0A8C0LNF2, A0A8C0S8K5, A0A8I3S5L2
      Related
      ENSCAFP00845030883.1, ENSCAFT00845039411.1
      Conserved Domains (2) summary
      PHA03247
      Location:46 → 336
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:359 → 388
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    9. XM_038675014.1 → XP_038530942.1  microtubule-associated protein tau isoform X15

      UniProtKB/TrEMBL
      A0A8C0LX36, A0A8C0ML91
      Conserved Domains (2) summary
      PHA03378
      Location:91 → 193
      PHA03378; EBNA-3B; Provisional
      pfam00418
      Location:217 → 247
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    10. XM_038675012.1 → XP_038530940.1  microtubule-associated protein tau isoform X13

      UniProtKB/TrEMBL
      A0A8C0LX36, A0A8C0ML91
      Conserved Domains (2) summary
      PHA03378
      Location:91 → 193
      PHA03378; EBNA-3B; Provisional
      pfam00418
      Location:217 → 246
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    11. XM_038675013.1 → XP_038530941.1  microtubule-associated protein tau isoform X14

      UniProtKB/TrEMBL
      A0A8C0LQR4, A0A8C0ML32
      Conserved Domains (2) summary
      PHA03307
      Location:21 → 222
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:246 → 276
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    12. XM_038675010.1 → XP_038530938.1  microtubule-associated protein tau isoform X11

      UniProtKB/TrEMBL
      A0A8C0LMU7, A0A8C0MRE3, A0A8I3S350
      Related
      ENSCAFP00845031103.1, ENSCAFT00845039706.1
      Conserved Domains (2) summary
      PHA03307
      Location:21 → 222
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:246 → 275
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    13. XM_038675009.1 → XP_038530937.1  microtubule-associated protein tau isoform X10

      UniProtKB/TrEMBL
      A0A8C0LMU7, A0A8C0MRE3, A0A8I3S350
      Conserved Domains (2) summary
      PHA03307
      Location:21 → 238
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:264 → 293
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    14. XM_038675011.1 → XP_038530939.1  microtubule-associated protein tau isoform X12

      UniProtKB/TrEMBL
      A0A8C0LQR4, A0A8C0ML32
      Conserved Domains (2) summary
      PHA03247
      Location:48 → 247
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:275 → 305
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    15. XM_038675008.1 → XP_038530936.1  microtubule-associated protein tau isoform X9

      UniProtKB/TrEMBL
      A0A8C0R8N3
      Conserved Domains (2) summary
      PHA03247
      Location:48 → 247
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:275 → 304
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    16. XM_038675007.1 → XP_038530935.1  microtubule-associated protein tau isoform X8

      UniProtKB/TrEMBL
      A0A8C0MY74, A0A8I3PET0
      Related
      ENSCAFP00845031011.1, ENSCAFT00845039578.1
      Conserved Domains (2) summary
      PHA03247
      Location:48 → 269
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:293 → 322
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    17. XM_038675000.1 → XP_038530928.1  microtubule-associated protein tau isoform X1

      UniProtKB/TrEMBL
      A0A8C0S849
      Related
      ENSCAFP00845031691.1, ENSCAFT00845040475.1
      Conserved Domains (3) summary
      PHA03247
      Location:304 → 652
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:21 → 384
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:674 → 703
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      10175159..10221409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      17303033..17349281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      17249716..17295984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      10679514..10725761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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