U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CAPN2 calpain 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 480118, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CAPN2provided by VGNC
    Official Full Name
    calpain 2provided by VGNC
    Primary source
    VGNC:VGNC:53334
    See related
    Ensembl:ENSCAFG00845013136
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CAPN2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (40166074..40204194, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (39815620..39853714, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (40285433..40323542, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (40007852..40045930, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (40016382..40054477, complement)

    Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872560 Neighboring gene tumor protein p53 binding protein 2 Neighboring gene calpain 8 Neighboring gene uncharacterized LOC119872561 Neighboring gene uncharacterized LOC111096723

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    calpain-2 catalytic subunit
    XP_038337464.1
    XP_038398823.1
    XP_038425753.1
    XP_038462941.1
    XP_038527666.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051811.1 Reference ROS_Cfam_1.0

      Range
      40166074..40204194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038671738.1 → XP_038527666.1  calpain-2 catalytic subunit

      UniProtKB/TrEMBL
      A0A8I3NDL3, A0A8I3NF92
      Related
      ENSCAFP00845018497.1, ENSCAFT00845023560.1
      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049267.1 Alternate UMICH_Zoey_3.1

      Range
      40007852..40045930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038481536.1 → XP_038337464.1  calpain-2 catalytic subunit

      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

      Range
      40016382..40054477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038607013.1 → XP_038462941.1  calpain-2 catalytic subunit

      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

      Range
      40285433..40323542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038542895.1 → XP_038398823.1  calpain-2 catalytic subunit

      UniProtKB/TrEMBL
      A0A8I3NDL3, A0A8I3NF92
      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      39815620..39853714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038569825.1 → XP_038425753.1  calpain-2 catalytic subunit

      UniProtKB/TrEMBL
      A0A8C0JS73, A0A8C0M6B8, A0A8C0SUD0, A0A8P0SIE2, A0A8P0SKP8
      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials