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    PRDX6 peroxiredoxin 6 [ Canis lupus familiaris (dog) ]

    Gene ID: 480069, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PRDX6provided by VGNC
    Official Full Name
    peroxiredoxin 6provided by VGNC
    Primary source
    VGNC:VGNC:44953
    See related
    Ensembl:ENSCAFG00845012128
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PRDX6 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (25414335..25427625, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (25195499..25208542, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (25560133..25573439, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (25333015..25346019, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (25411171..25424446, complement)

    Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 45 Neighboring gene testis expressed 50 Neighboring gene solute carrier family 9 member C2 (putative) Neighboring gene translationally-controlled tumor protein-like Neighboring gene 28S ribosomal protein S36, mitochondrial-like Neighboring gene elongation factor 1-alpha 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Peroxiredoxin 6 Protects Neoplastic Cells against Apoptosis in Canine Haemangiosarcoma. Anwar Sh, et al. J Comp Pathol, 2016 Jul. PMID 27306414
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Marked expression of PRDX6 was seen in spontaneously arising primary canine haemangiosarcoma
      Title: Overexpression of Peroxiredoxin 6 Protects Neoplastic Cells against Apoptosis in Canine Haemangiosarcoma.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxiredoxin-6
    XP_038337073.1
    XP_038398431.1
    XP_038462584.1
    XP_038527259.1
    XP_537190.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051811.1 Reference ROS_Cfam_1.0

      Range
      25414335..25427625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038671331.1 → XP_038527259.1  peroxiredoxin-6

      UniProtKB/TrEMBL
      A0A8C0KY60, A0A8C0SEH4, A0A8C0SEM2, A0A8I3NWQ3
      Related
      ENSCAFP00845016941.1, ENSCAFT00845021559.1
      Conserved Domains (1) summary
      cd03016
      Location:7 → 222
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049267.1 Alternate UMICH_Zoey_3.1

      Range
      25333015..25346019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038481145.1 → XP_038337073.1  peroxiredoxin-6

      Conserved Domains (1) summary
      cd03016
      Location:7 → 222
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

      Range
      25411171..25424446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038606656.1 → XP_038462584.1  peroxiredoxin-6

      Conserved Domains (1) summary
      cd03016
      Location:7 → 222
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

      Range
      25560133..25573439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038542503.1 → XP_038398431.1  peroxiredoxin-6

      UniProtKB/TrEMBL
      A0A8C0KY60, A0A8C0SEH4, A0A8C0SEM2, A0A8I3NWQ3
      Conserved Domains (1) summary
      cd03016
      Location:7 → 222
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      25195499..25208542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_537190.7 → XP_537190.5  peroxiredoxin-6

      UniProtKB/TrEMBL
      A0A8C0KY60, A0A8C0SEH4, A0A8C0SEM2, A0A8I3NWQ3
      Conserved Domains (1) summary
      cd03016
      Location:7 → 222
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...
    Nucleotide Protein
    Heading Accession and Version

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