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    SORL1 sortilin related receptor 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 479408, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SORL1provided by VGNC
    Official Full Name
    sortilin related receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:46663
    See related
    Ensembl:ENSCAFG00845013384
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SORL1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (12443942..12600792, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (12548775..12705458, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (12525262..12682112, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (12550420..12707102, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (12486757..12643601, complement)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096096 Neighboring gene uncharacterized LOC111095804 Neighboring gene uncharacterized LOC119871795 Neighboring gene uncharacterized LOC119871796 Neighboring gene sterol-C5-desaturase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein retention in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein targeting to lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sortilin-related receptor
    Names
    sortilin-related receptor, L(DLR class) A repeats-containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      12443942..12600792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038664608.1 → XP_038520536.1  sortilin-related receptor

      UniProtKB/TrEMBL
      A0A8C0LUZ0
      Related
      ENSCAFP00845018836.1, ENSCAFT00845023986.1
      Conserved Domains (9) summary
      smart00192
      Location:1271 → 1298
      LDLa; Low-density lipoprotein receptor domain class A
      smart00060
      Location:1739 → 1819
      FN3; Fibronectin type 3 domain
      smart00135
      Location:814 → 856
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00602
      Location:114 → 743
      VPS10; VPS10 domain
      cd00063
      Location:1641 → 1732
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00112
      Location:1363 → 1393
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:1147 → 1182
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:880 → 919
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam16472
      Location:861 → 1001
      DUF5050; Domain of unknown function (DUF5050)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      12550420..12707102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038474728.1 → XP_038330656.1  sortilin-related receptor

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      12486757..12643601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038600069.1 → XP_038455997.1  sortilin-related receptor

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      12525262..12682112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038535871.1 → XP_038391799.1  sortilin-related receptor

      UniProtKB/TrEMBL
      A0A8C0LUZ0

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      12548775..12705458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_536545.7 → XP_536545.2  sortilin-related receptor

      UniProtKB/TrEMBL
      A0A8C0LUZ0
      Conserved Domains (9) summary
      smart00192
      Location:1271 → 1298
      LDLa; Low-density lipoprotein receptor domain class A
      smart00060
      Location:1739 → 1819
      FN3; Fibronectin type 3 domain
      smart00135
      Location:814 → 856
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00602
      Location:114 → 743
      VPS10; VPS10 domain
      cd00063
      Location:1641 → 1732
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00112
      Location:1363 → 1393
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:1147 → 1182
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:880 → 919
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam15901
      Location:578 → 743
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
    Nucleotide Protein
    Heading Accession and Version

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