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    NRG3 neuregulin 3 [ Canis lupus familiaris (dog) ]

    Gene ID: 479263, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NRG3provided by VGNC
    Official Full Name
    neuregulin 3provided by VGNC
    Primary source
    VGNC:VGNC:51907
    See related
    Ensembl:ENSCAFG00845015872
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See NRG3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (30834334..31875634)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (30570501..31546936)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (31385545..32426952)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (30699630..31739836)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (30896586..31931272)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119871492 Neighboring gene uncharacterized LOC119871491 Neighboring gene uncharacterized LOC119871493 Neighboring gene uncharacterized LOC119871495 Neighboring gene uncharacterized LOC102151392 Neighboring gene dnaJ homolog subfamily B member 6-like Neighboring gene uncharacterized LOC119871494 Neighboring gene uncharacterized LOC111095517 Neighboring gene uncharacterized LOC102151261 Neighboring gene uncharacterized LOC100855646 Neighboring gene uncharacterized LOC102151156 Neighboring gene serine/threonine-protein kinase MARK2-like Neighboring gene 60S ribosomal protein L9-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NRG3/ERBB4 signaling cascade as a novel therapeutic target for canine glioma. Noguchi S, et al. Exp Cell Res, 2021 Mar 15. PMID 33508276
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The NRG3/ERBB4 signaling cascade as a novel therapeutic target for canine glioma.
      Title: The NRG3/ERBB4 signaling cascade as a novel therapeutic target for canine glioma.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chemorepellent activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pro-neuregulin-3, membrane-bound isoform; LOW QUALITY PROTEIN: pro-neuregulin-3, membrane-bound isoform

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      30834334..31875634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038663089.1 → XP_038519017.1  pro-neuregulin-3, membrane-bound isoform isoform X1

      UniProtKB/TrEMBL
      A0A8C0TTC6, A0A8I3NVK5
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    2. XM_038663092.1 → XP_038519020.1  pro-neuregulin-3, membrane-bound isoform isoform X4

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    3. XM_038663090.1 → XP_038519018.1  pro-neuregulin-3, membrane-bound isoform isoform X2

      UniProtKB/TrEMBL
      A0A8C0TTC6, A0A8I3NVK5
      Related
      ENSCAFP00845022334.1, ENSCAFT00845028392.1
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    4. XM_038663093.1 → XP_038519021.1  pro-neuregulin-3, membrane-bound isoform isoform X5

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Related
      ENSCAFP00845022360.1, ENSCAFT00845028424.1
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    5. XM_038663091.1 → XP_038519019.1  pro-neuregulin-3, membrane-bound isoform isoform X3

      UniProtKB/TrEMBL
      A0A8C0TTC6, A0A8I3NVK5
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    6. XM_038663094.1 → XP_038519022.1  pro-neuregulin-3, membrane-bound isoform isoform X6

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    7. XM_038663095.1 → XP_038519023.1  pro-neuregulin-3, membrane-bound isoform isoform X7

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      30699630..31739836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038473422.1 → XP_038329350.1  LOW QUALITY PROTEIN: pro-neuregulin-3, membrane-bound isoform isoform X2

      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      30896586..31931272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038598817.1 → XP_038454745.1  pro-neuregulin-3, membrane-bound isoform isoform X1

      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    2. XM_038598820.1 → XP_038454748.1  pro-neuregulin-3, membrane-bound isoform isoform X4

      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    3. XM_038598818.1 → XP_038454746.1  pro-neuregulin-3, membrane-bound isoform isoform X2

      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    4. XM_038598821.1 → XP_038454749.1  pro-neuregulin-3, membrane-bound isoform isoform X5

      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    5. XM_038598819.1 → XP_038454747.1  pro-neuregulin-3, membrane-bound isoform isoform X3

      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    6. XM_038598822.1 → XP_038454750.1  pro-neuregulin-3, membrane-bound isoform isoform X6

      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    7. XM_038598823.1 → XP_038454751.1  pro-neuregulin-3, membrane-bound isoform isoform X7

      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      31385545..32426952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038534491.1 → XP_038390419.1  pro-neuregulin-3, membrane-bound isoform isoform X1

      UniProtKB/TrEMBL
      A0A8C0TTC6, A0A8I3NVK5
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    2. XM_038534494.1 → XP_038390422.1  pro-neuregulin-3, membrane-bound isoform isoform X4

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    3. XM_038534492.1 → XP_038390420.1  pro-neuregulin-3, membrane-bound isoform isoform X2

      UniProtKB/TrEMBL
      A0A8C0TTC6, A0A8I3NVK5
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    4. XM_038534495.1 → XP_038390423.1  pro-neuregulin-3, membrane-bound isoform isoform X5

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    5. XM_038534493.1 → XP_038390421.1  pro-neuregulin-3, membrane-bound isoform isoform X3

      UniProtKB/TrEMBL
      A0A8C0TTC6, A0A8I3NVK5
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    6. XM_038534496.1 → XP_038390424.1  pro-neuregulin-3, membrane-bound isoform isoform X6

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    7. XM_038534497.1 → XP_038390425.1  pro-neuregulin-3, membrane-bound isoform isoform X7

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      30570501..31546936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014112927.3 → XP_013968402.1  pro-neuregulin-3, membrane-bound isoform isoform X1

      UniProtKB/TrEMBL
      A0A8C0TTC6, A0A8I3NVK5
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    2. XM_014112931.3 → XP_013968406.1  pro-neuregulin-3, membrane-bound isoform isoform X4

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    3. XM_014112928.3 → XP_013968403.1  pro-neuregulin-3, membrane-bound isoform isoform X2

      UniProtKB/TrEMBL
      A0A8C0TTC6, A0A8I3NVK5
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    4. XM_003434488.5 → XP_003434536.1  pro-neuregulin-3, membrane-bound isoform isoform X5

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    5. XM_014112929.3 → XP_013968404.1  pro-neuregulin-3, membrane-bound isoform isoform X3

      UniProtKB/TrEMBL
      A0A8C0TTC6, A0A8I3NVK5
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    6. XM_038492818.1 → XP_038348746.1  pro-neuregulin-3, membrane-bound isoform isoform X6

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional

    7. XM_005619098.4 → XP_005619155.1  pro-neuregulin-3, membrane-bound isoform isoform X7

      UniProtKB/TrEMBL
      A0A8C0LVS7, A0A8I3NYS3
      Conserved Domains (2) summary
      PHA02887
      Location:284 → 337
      PHA02887; EGF-like protein; Provisional
      PHA03378
      Location:144 → 223
      PHA03378; EBNA-3B; Provisional
    Nucleotide Protein
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