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    IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [ Canis lupus familiaris (dog) ]

    Gene ID: 479066, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IDH3Aprovided by VGNC
    Official Full Name
    isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:53184
    See related
    Ensembl:ENSCAFG00845006975
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See IDH3A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (58769639..58786830)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (60993181..61010332)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (58823194..58840363)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (58266135..58283304)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (58474154..58491092)

    Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene uncharacterized LOC102157379 Neighboring gene microRNA mir-8900

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Light-activated BioID - an optically activated proximity labeling system to study protein-protein interactions. Shafraz O, et al. J Cell Sci, 2023 Oct 1. PMID 37756605, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables isocitrate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isocitrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Names
    Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Isocitric dehydrogenase subunit alpha
    NAD(+)-specific ICDH subunit alpha
    isocitrate dehydrogenase (NAD(+)) 3 alpha
    isocitrate dehydrogenase 3 (NAD(+)) alpha
    XP_005618493.1
    XP_022272730.1
    XP_038328036.1
    XP_038328037.1
    XP_038328038.1
    XP_038328039.1
    XP_038328040.1
    XP_038333191.1
    XP_038333202.1
    XP_038388977.1
    XP_038388978.1
    XP_038388979.1
    XP_038388980.1
    XP_038388981.1
    XP_038453305.1
    XP_038453306.1
    XP_038453307.1
    XP_038453308.1
    XP_038453309.1
    XP_038517487.1
    XP_038517488.1
    XP_038517489.1
    XP_038517490.1
    XP_038517491.1
    XP_536213.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051807.1 Reference ROS_Cfam_1.0

      Range
      58769639..58786830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038661559.1 → XP_038517487.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8C0MAD2, A0A8C0R1I6, A0A8I3NG17
      Related
      ENSCAFP00845009695.1, ENSCAFT00845012402.1
      Conserved Domains (1) summary
      TIGR00175
      Location:29 → 362
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    2. XM_038661560.1 → XP_038517488.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X2

      Conserved Domains (1) summary
      TIGR00175
      Location:22 → 354
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    3. XM_038661562.1 → XP_038517490.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    4. XM_038661563.1 → XP_038517491.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    5. XM_038661561.1 → XP_038517489.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049263.1 Alternate UMICH_Zoey_3.1

      Range
      58266135..58283304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038472108.1 → XP_038328036.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X1

      Conserved Domains (1) summary
      TIGR00175
      Location:29 → 362
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    2. XM_038472109.1 → XP_038328037.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X2

      Conserved Domains (1) summary
      TIGR00175
      Location:22 → 354
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    3. XM_038472111.1 → XP_038328039.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    4. XM_038472112.1 → XP_038328040.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    5. XM_038472110.1 → XP_038328038.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

      Range
      58474154..58491092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038597377.1 → XP_038453305.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X1

      Conserved Domains (1) summary
      TIGR00175
      Location:29 → 362
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    2. XM_038597378.1 → XP_038453306.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X2

      Conserved Domains (1) summary
      TIGR00175
      Location:22 → 354
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    3. XM_038597380.1 → XP_038453308.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    4. XM_038597381.1 → XP_038453309.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    5. XM_038597379.1 → XP_038453307.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

      Range
      58823194..58840363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038533049.1 → XP_038388977.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8C0MAD2, A0A8C0R1I6, A0A8I3NG17
      Conserved Domains (1) summary
      TIGR00175
      Location:29 → 362
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    2. XM_038533050.1 → XP_038388978.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X2

      Conserved Domains (1) summary
      TIGR00175
      Location:22 → 354
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    3. XM_038533052.1 → XP_038388980.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    4. XM_038533053.1 → XP_038388981.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    5. XM_038533051.1 → XP_038388979.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      60993181..61010332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_536213.7 → XP_536213.2  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8C0MAD2, A0A8C0R1I6, A0A8I3NG17
      Conserved Domains (1) summary
      TIGR00175
      Location:29 → 362
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    2. XM_038477263.1 → XP_038333191.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X2

      Conserved Domains (1) summary
      TIGR00175
      Location:22 → 354
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    3. XM_005618436.4 → XP_005618493.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    4. XM_038477274.1 → XP_038333202.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    5. XM_022417022.2 → XP_022272730.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00445
      Location:1 → 312
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54836.1 GenPept UniProtKB/Swiss-Prot:P54836

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