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    FAN1 FANCD2 and FANCI associated nuclease 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 479017, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FAN1provided by VGNC
    Official Full Name
    FANCD2 and FANCI associated nuclease 1provided by VGNC
    Primary source
    VGNC:VGNC:40715
    See related
    Ensembl:ENSCAFG00845021476
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    MTMR15
    Orthologs
    human mouse all
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    Genomic context

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    See FAN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (38394079..38430387, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (40698132..40737657, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (38383672..38423530, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (37919389..37955716, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (38179558..38215917, complement)

    Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel subfamily M member 1 Neighboring gene microRNA mir-211 Neighboring gene uncharacterized LOC102155962 Neighboring gene myotubularin related protein 10 Neighboring gene M-phase phosphoprotein 10 Neighboring gene methylmalonyl-CoA epimerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 5'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flap-structured DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fanconi-associated nuclease 1
    Names
    FANCD2/FANCI-associated nuclease 1
    myotubularin related protein 15
    XP_005618326.2
    XP_005618327.2
    XP_005618328.2
    XP_005618329.2
    XP_013967838.2
    XP_013967839.2
    XP_038327604.1
    XP_038327605.1
    XP_038327606.1
    XP_038327607.1
    XP_038327608.1
    XP_038327609.1
    XP_038327610.1
    XP_038388531.1
    XP_038388532.1
    XP_038388533.1
    XP_038388534.1
    XP_038388535.1
    XP_038388536.1
    XP_038452835.1
    XP_038452837.1
    XP_038452838.1
    XP_038452839.1
    XP_038452840.1
    XP_038452841.1
    XP_038452842.1
    XP_038517046.1
    XP_038517047.1
    XP_038517048.1
    XP_038517049.1
    XP_038517050.1
    XP_038517051.1
    XP_038517052.1
    XP_856650.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051807.1 Reference ROS_Cfam_1.0

      Range
      38394079..38430387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038661118.1 → XP_038517046.1  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0M3S1, A0A8C0MAV8, A0A8I3PL86
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    2. XM_038661120.1 → XP_038517048.1  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0M3S1, A0A8C0MAV8, A0A8I3PL86
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    3. XM_038661122.1 → XP_038517050.1  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0M3S1, A0A8C0MAV8, A0A8I3PL86
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    4. XM_038661121.1 → XP_038517049.1  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0M3S1, A0A8C0MAV8, A0A8I3PL86
      Related
      ENSCAFP00845029702.1, ENSCAFT00845037905.1
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    5. XM_038661119.1 → XP_038517047.1  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0M3S1, A0A8C0MAV8, A0A8I3PL86
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    6. XM_038661123.1 → XP_038517051.1  fanconi-associated nuclease 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0M3S1, A0A8C0RBY5
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 982
      FAN1-like; repair nuclease FAN1

    7. XM_038661124.1 → XP_038517052.1  fanconi-associated nuclease 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0M7E5
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 943
      FAN1-like; repair nuclease FAN1

    RNA

    1. XR_005424450.1 RNA Sequence

    2. XR_005424451.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049263.1 Alternate UMICH_Zoey_3.1

      Range
      37919389..37955716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038471677.1 → XP_038327605.1  fanconi-associated nuclease 1 isoform X1

    2. XM_038471679.1 → XP_038327607.1  fanconi-associated nuclease 1 isoform X1

    3. XM_038471680.1 → XP_038327608.1  fanconi-associated nuclease 1 isoform X1

    4. XM_038471678.1 → XP_038327606.1  fanconi-associated nuclease 1 isoform X1

    5. XM_038471681.1 → XP_038327609.1  fanconi-associated nuclease 1 isoform X2

    6. XM_038471676.1 → XP_038327604.1  fanconi-associated nuclease 1 isoform X1

    7. XM_038471682.1 → XP_038327610.1  fanconi-associated nuclease 1 isoform X3

    RNA

    1. XR_005323249.1 RNA Sequence

    2. XR_005323250.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

      Range
      38179558..38215917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038596907.1 → XP_038452835.1  fanconi-associated nuclease 1 isoform X1

      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    2. XM_038596910.1 → XP_038452838.1  fanconi-associated nuclease 1 isoform X1

      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    3. XM_038596912.1 → XP_038452840.1  fanconi-associated nuclease 1 isoform X1

      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    4. XM_038596911.1 → XP_038452839.1  fanconi-associated nuclease 1 isoform X1

      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    5. XM_038596909.1 → XP_038452837.1  fanconi-associated nuclease 1 isoform X1

      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    6. XM_038596913.1 → XP_038452841.1  fanconi-associated nuclease 1 isoform X2

      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 982
      FAN1-like; repair nuclease FAN1

    7. XM_038596914.1 → XP_038452842.1  fanconi-associated nuclease 1 isoform X3

      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 943
      FAN1-like; repair nuclease FAN1

    RNA

    1. XR_005391432.1 RNA Sequence

    2. XR_005391433.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

      Range
      38383672..38423530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038532604.1 → XP_038388532.1  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8C0T694

    2. XM_038532606.1 → XP_038388534.1  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8C0T694

    3. XM_038532605.1 → XP_038388533.1  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8C0T694

    4. XM_038532607.1 → XP_038388535.1  fanconi-associated nuclease 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8C0Z278

    5. XM_038532603.1 → XP_038388531.1  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8C0T694

    6. XM_038532608.1 → XP_038388536.1  fanconi-associated nuclease 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0T5A8

    RNA

    1. XR_005356908.1 RNA Sequence

    2. XR_005356909.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      40698132..40737657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005618271.4 → XP_005618328.2  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8P0SFF1
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    2. XM_005618270.3 → XP_005618327.2  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8P0SFF1
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    3. XM_005618272.3 → XP_005618329.2  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8P0SFF1
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    4. XM_851557.6 → XP_856650.2  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8P0SFF1
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    5. XM_005618269.4 → XP_005618326.2  fanconi-associated nuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8P0SFF1
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 1029
      FAN1-like; repair nuclease FAN1

    6. XM_014112363.3 → XP_013967838.2  fanconi-associated nuclease 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0T3F4, A0A8P0P3K3
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 982
      FAN1-like; repair nuclease FAN1

    7. XM_014112364.3 → XP_013967839.2  fanconi-associated nuclease 1 isoform X3

      UniProtKB/TrEMBL
      A0A8P0P8H3
      Conserved Domains (2) summary
      smart00734
      Location:40 → 61
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd22326
      Location:385 → 943
      FAN1-like; repair nuclease FAN1

    RNA

    1. XR_002625025.2 RNA Sequence

    2. XR_002625026.2 RNA Sequence

    Nucleotide Protein
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