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    MARK1 microtubule affinity regulating kinase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 478965, updated on 17-Aug-2024

    Summary

    Official Symbol
    MARK1provided by VGNC
    Official Full Name
    microtubule affinity regulating kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:49921
    See related
    Ensembl:ENSCAFG00845030076
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    NEW
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    Genomic context

    See MARK1 in Genome Data Viewer
    Location:
    chromosome: 38
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 38 NC_051842.1 (15263226..15379605)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 38 NC_006620.4 (15268336..15385001)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 38 NC_049259.1 (15905948..16022402)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 38 NC_049298.1 (15270806..15387062)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 38 NC_049779.1 (15625161..15741308)

    Chromosome 38 - NC_051842.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111094612 Neighboring gene putative methyltransferase C9orf114 Neighboring gene 60S ribosomal protein L35-like Neighboring gene protein SET-like Neighboring gene uncharacterized LOC119868046

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase MARK1
    XP_038304398.1
    XP_038304399.1
    XP_038304400.1
    XP_038304401.1
    XP_038304402.1
    XP_038304403.1
    XP_038319980.1
    XP_038319981.1
    XP_038319982.1
    XP_038319983.1
    XP_038319984.1
    XP_038319985.1
    XP_038378302.1
    XP_038378303.1
    XP_038378304.1
    XP_038378305.1
    XP_038378306.1
    XP_038378307.1
    XP_038442104.1
    XP_038442105.1
    XP_038442106.1
    XP_038442107.1
    XP_038442108.1
    XP_038442109.1
    XP_038506511.1
    XP_038506512.1
    XP_038506513.1
    XP_038506514.1
    XP_038506515.1
    XP_038506516.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051842.1 Reference ROS_Cfam_1.0

      Range
      15263226..15379605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038448470.1XP_038304398.1  serine/threonine-protein kinase MARK1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0PB27, A0A8C0RR74, A0A8I3Q3E4, A0A8I3Q5L0
      Related
      ENSCAFP00845041899.1, ENSCAFT00845053341.1
      Conserved Domains (3) summary
      cd12196
      Location:700797
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. XM_038448471.1XP_038304399.1  serine/threonine-protein kinase MARK1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3S7F6, A0A8P0TK44
      Related
      ENSCAFP00845041873.1, ENSCAFT00845053315.1
      Conserved Domains (3) summary
      cd12196
      Location:696793
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_038448472.1XP_038304400.1  serine/threonine-protein kinase MARK1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0RR20, A0A8C0RR74, A0A8I3Q5L0
      Related
      ENSCAFP00845041950.1, ENSCAFT00845053399.1
      Conserved Domains (3) summary
      cd12196
      Location:681778
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_038448473.1XP_038304401.1  serine/threonine-protein kinase MARK1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (3) summary
      cd12196
      Location:645742
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_038448474.1XP_038304402.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    6. XM_038448475.1XP_038304403.1  serine/threonine-protein kinase MARK1 isoform X6

      UniProtKB/TrEMBL
      A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049298.1 Alternate UMICH_Zoey_3.1

      Range
      15270806..15387062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038522374.1XP_038378302.1  serine/threonine-protein kinase MARK1 isoform X1

      Conserved Domains (3) summary
      cd12196
      Location:700797
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. XM_038522375.1XP_038378303.1  serine/threonine-protein kinase MARK1 isoform X2

      Conserved Domains (3) summary
      cd12196
      Location:696793
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_038522376.1XP_038378304.1  serine/threonine-protein kinase MARK1 isoform X3

      Conserved Domains (3) summary
      cd12196
      Location:681778
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_038522377.1XP_038378305.1  serine/threonine-protein kinase MARK1 isoform X4

      Conserved Domains (3) summary
      cd12196
      Location:645742
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_038522378.1XP_038378306.1  serine/threonine-protein kinase MARK1 isoform X5

      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    6. XM_038522379.1XP_038378307.1  serine/threonine-protein kinase MARK1 isoform X6

      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049779.1 Alternate UNSW_CanFamBas_1.0

      Range
      15625161..15741308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038650583.1XP_038506511.1  serine/threonine-protein kinase MARK1 isoform X1

      Conserved Domains (3) summary
      cd12196
      Location:700797
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. XM_038650584.1XP_038506512.1  serine/threonine-protein kinase MARK1 isoform X2

      Conserved Domains (3) summary
      cd12196
      Location:696793
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_038650585.1XP_038506513.1  serine/threonine-protein kinase MARK1 isoform X3

      Conserved Domains (3) summary
      cd12196
      Location:681778
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_038650586.1XP_038506514.1  serine/threonine-protein kinase MARK1 isoform X4

      Conserved Domains (3) summary
      cd12196
      Location:645742
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_038650587.1XP_038506515.1  serine/threonine-protein kinase MARK1 isoform X5

      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    6. XM_038650588.1XP_038506516.1  serine/threonine-protein kinase MARK1 isoform X6

      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049259.1 Alternate UU_Cfam_GSD_1.0

      Range
      15905948..16022402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038586176.1XP_038442104.1  serine/threonine-protein kinase MARK1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0PB27, A0A8C0RR74, A0A8I3Q3E4, A0A8I3Q5L0
      Conserved Domains (3) summary
      cd12196
      Location:700797
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. XM_038586177.1XP_038442105.1  serine/threonine-protein kinase MARK1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3S7F6, A0A8P0TK44
      Conserved Domains (3) summary
      cd12196
      Location:696793
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_038586178.1XP_038442106.1  serine/threonine-protein kinase MARK1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0RR20, A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (3) summary
      cd12196
      Location:681778
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_038586179.1XP_038442107.1  serine/threonine-protein kinase MARK1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (3) summary
      cd12196
      Location:645742
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_038586180.1XP_038442108.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    6. XM_038586181.1XP_038442109.1  serine/threonine-protein kinase MARK1 isoform X6

      UniProtKB/TrEMBL
      A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006620.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      15268336..15385001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038464052.1XP_038319980.1  serine/threonine-protein kinase MARK1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0PB27, A0A8C0RR74, A0A8I3Q3E4, A0A8I3Q5L0
      Conserved Domains (3) summary
      cd12196
      Location:700797
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. XM_038464053.1XP_038319981.1  serine/threonine-protein kinase MARK1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3S7F6, A0A8P0TK44
      Conserved Domains (3) summary
      cd12196
      Location:696793
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_038464054.1XP_038319982.1  serine/threonine-protein kinase MARK1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0RR20, A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (3) summary
      cd12196
      Location:681778
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_038464055.1XP_038319983.1  serine/threonine-protein kinase MARK1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (3) summary
      cd12196
      Location:645742
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_038464056.1XP_038319984.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    6. XM_038464057.1XP_038319985.1  serine/threonine-protein kinase MARK1 isoform X6

      UniProtKB/TrEMBL
      A0A8C0RR74, A0A8I3Q5L0
      Conserved Domains (2) summary
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases