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    ACVR1 activin A receptor type 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 478757, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ACVR1provided by VGNC
    Official Full Name
    activin A receptor type 1provided by VGNC
    Primary source
    VGNC:VGNC:37561
    See related
    Ensembl:ENSCAFG00845026311
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See ACVR1 in Genome Data Viewer
    Location:
    chromosome: 36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (3865484..3991973, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (3880162..4006562, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (3965356..4091837, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (3867397..3993826, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (3927214..4053637, complement)

    Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111094190 Neighboring gene uncharacterized LOC102152599 Neighboring gene cytohesin 1 interacting protein Neighboring gene activin A receptor type 1C Neighboring gene uncharacterized LOC111094310 Neighboring gene uncharacterized LOC111094311 Neighboring gene uncharacterized LOC119867792 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106558297 Neighboring gene coiled-coil domain containing 148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transforming growth factor beta receptor activity, type I IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BMP receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activin receptor type-1
    XP_005640253.1
    XP_038302711.1
    XP_038302712.1
    XP_038302713.1
    XP_038302714.1
    XP_038319224.1
    XP_038319225.1
    XP_038319226.1
    XP_038376813.1
    XP_038376814.1
    XP_038376815.1
    XP_038376816.1
    XP_038440482.1
    XP_038440483.1
    XP_038440484.1
    XP_038440485.1
    XP_038504901.1
    XP_038504902.1
    XP_038504903.1
    XP_038504904.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051840.1 Reference ROS_Cfam_1.0

      Range
      3865484..3991973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038446784.1 → XP_038302712.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Related
      ENSCAFP00845036443.1, ENSCAFT00845046412.1
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    2. XM_038446783.1 → XP_038302711.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    3. XM_038446786.1 → XP_038302714.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    4. XM_038446785.1 → XP_038302713.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049296.1 Alternate UMICH_Zoey_3.1

      Range
      3867397..3993826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038520886.1 → XP_038376814.1  activin receptor type-1

      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    2. XM_038520885.1 → XP_038376813.1  activin receptor type-1

      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    3. XM_038520888.1 → XP_038376816.1  activin receptor type-1

      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    4. XM_038520887.1 → XP_038376815.1  activin receptor type-1

      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

      Range
      3927214..4053637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038648974.1 → XP_038504902.1  activin receptor type-1

      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    2. XM_038648973.1 → XP_038504901.1  activin receptor type-1

      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    3. XM_038648976.1 → XP_038504904.1  activin receptor type-1

      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    4. XM_038648975.1 → XP_038504903.1  activin receptor type-1

      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

      Range
      3965356..4091837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038584555.1 → XP_038440483.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    2. XM_038584554.1 → XP_038440482.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    3. XM_038584557.1 → XP_038440485.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    4. XM_038584556.1 → XP_038440484.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      3880162..4006562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038463297.1 → XP_038319225.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    2. XM_038463296.1 → XP_038319224.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    3. XM_005640196.4 → XP_005640253.1  activin receptor type-1

      See identical proteins and their annotated locations for XP_005640253.1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    4. XM_038463298.1 → XP_038319226.1  activin receptor type-1

      UniProtKB/TrEMBL
      A0A8C0KA33, A0A8C0MPL7, A0A8C0MQ83, A0A8I3PSN0
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
    Nucleotide Protein
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