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    HADH hydroxyacyl-CoA dehydrogenase [ Canis lupus familiaris (dog) ]

    Gene ID: 478506, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HADHprovided by VGNC
    Official Full Name
    hydroxyacyl-CoA dehydrogenaseprovided by VGNC
    Primary source
    VGNC:VGNC:41584
    See related
    Ensembl:ENSCAFG00845029127
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See HADH in Genome Data Viewer
    Location:
    chromosome: 32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (28689480..28735351)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (13516288..13562132, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (11383587..11429427, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (28682743..28728360)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (28427283..28473178)

    Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene sphingomyelin synthase 2 Neighboring gene uncharacterized LOC102151722 Neighboring gene cytochrome P450 family 2 subfamily U member 1 Neighboring gene uncharacterized LOC111093692 Neighboring gene lymphoid enhancer binding factor 1 Neighboring gene eukaryotic translation initiation factor 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Light-activated BioID - an optically activated proximity labeling system to study protein-protein interactions. Shafraz O, et al. J Cell Sci, 2023 Oct 1. PMID 37756605, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
    Names
    hydroxyacyl-Coenzyme A dehydrogenase
    XP_038300260.1
    XP_038374648.1
    XP_038437874.1
    XP_038502597.1
    XP_535685.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051836.1 Reference ROS_Cfam_1.0

      Range
      28689480..28735351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038444332.1 → XP_038300260.1  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

      UniProtKB/TrEMBL
      A0A8C0KAK2, A0A8C0PEV9, A0A8C0TB33
      Related
      ENSCAFP00845040527.1, ENSCAFT00845051653.1
      Conserved Domains (1) summary
      COG1250
      Location:27 → 313
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049292.1 Alternate UMICH_Zoey_3.1

      Range
      28682743..28728360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038518720.1 → XP_038374648.1  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

      Conserved Domains (1) summary
      COG1250
      Location:27 → 313
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

      Range
      28427283..28473178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038646669.1 → XP_038502597.1  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

      Conserved Domains (1) summary
      COG1250
      Location:27 → 313
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

      Range
      11383587..11429427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038581946.1 → XP_038437874.1  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

      UniProtKB/TrEMBL
      A0A8C0KAK2, A0A8C0PEV9, A0A8C0TB33
      Conserved Domains (1) summary
      COG1250
      Location:27 → 313
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      13516288..13562132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_535685.7 → XP_535685.2  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for XP_535685.2

      UniProtKB/TrEMBL
      A0A8C0PEV9, A0A8P0TBX0
      Conserved Domains (3) summary
      COG1250
      Location:25 → 311
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
      pfam00725
      Location:214 → 311
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:27 → 212
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
    Nucleotide Protein
    Heading Accession and Version

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