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    ITGB1 integrin subunit beta 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 477956, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ITGB1provided by VGNC
    Official Full Name
    integrin subunit beta 1provided by VGNC
    Primary source
    VGNC:VGNC:42136
    See related
    Ensembl:ENSCAFG00845002947
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See ITGB1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (4006817..4053107)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (3811003..3857059)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (3939078..3985170)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (3785306..3831383)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (3819236..3865356)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene neuropilin 1 Neighboring gene uncharacterized LOC106560035 Neighboring gene uncharacterized LOC119870087 Neighboring gene rRNA-processing protein FCF1 homolog Neighboring gene coiled-coil domain containing 7 Neighboring gene uncharacterized LOC119875646

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Galectin-3 modulates the polarized surface delivery of β1-integrin in epithelial cells. Hönig E, et al. J Cell Sci, 2018 Jun 11. PMID 29748377
    2. Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism. Hunter MP, et al. Am J Physiol Cell Physiol, 2010 Jul. PMID 20457839, Free PMC Article
    3. G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis. Kong T, et al. Mol Biol Cell, 2009 Nov. PMID 19776354, Free PMC Article
    4. Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV. Friedrichs J, et al. J Biol Chem, 2008 Nov 21. PMID 18806266
    5. A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Wang CZ, et al. Mol Biol Cell, 2006 Jun. PMID 16611743, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Galectin-3 targets newly synthesized beta1-integrin to the apical membrane and promotes apical delivery of beta1-integrin internalized from the basolateral membrane.
      Title: Galectin-3 modulates the polarized surface delivery of β1-integrin in epithelial cells.
    2. Pak1-induced branching morphogenesis in 3D MDCK cell culture requires PIX binding and beta1-integrin signaling.
      Title: Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism.
    3. Data demonstrate that G alpha 12 inhibits interaction of MDCK cells with collagen-I, the major ligand for alpha2 beta1 integrin, and regulates epithelial cell spreading and migration necessary for normal tubulogenesis.
      Title: G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis.
    4. galectin-3 influences integrin alpha(2)beta(1)-mediated adhesion complex formation by altering receptor clustering
      Title: Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables C-X3-C chemokine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables collagen binding involved in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibronectin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin beta-1
    Names
    integrin beta 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      4006817..4053107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038658027.1 → XP_038513955.1  integrin beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N387, A0A8C0PYR6, A0A8I3MMM0, A0A8I3MMP8
      Related
      ENSCAFP00845004324.1, ENSCAFT00845005439.1
      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA

    2. XM_038658028.1 → XP_038513956.1  integrin beta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KDT4, A0A8C0PYR6, A0A8I3MMM0
      Related
      ENSCAFP00845004285.1, ENSCAFT00845005381.1
      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      3785306..3831383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038469003.1 → XP_038324931.1  integrin beta-1 isoform X1

      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA

    2. XM_038469004.1 → XP_038324932.1  integrin beta-1 isoform X2

      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      3819236..3865356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038593949.1 → XP_038449877.1  integrin beta-1 isoform X1

      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA

    2. XM_038593950.1 → XP_038449878.1  integrin beta-1 isoform X2

      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      3939078..3985170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038529709.1 → XP_038385637.1  integrin beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N387, A0A8C0PYR6, A0A8I3MMM0, A0A8I3MMP8
      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA

    2. XM_038529710.1 → XP_038385638.1  integrin beta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KDT4, A0A8C0PYR6, A0A8I3MMM0
      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      3811003..3857059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038455730.1 → XP_038311658.1  integrin beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N387, A0A8C0PYR6, A0A8I3MMM0, A0A8I3MMP8
      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA

    2. XM_038455731.1 → XP_038311659.1  integrin beta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KDT4, A0A8C0PYR6, A0A8I3MMM0
      Conserved Domains (4) summary
      smart00187
      Location:34 → 464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:640 → 727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:755 → 795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      NF033759
      Location:472 → 650
      exchanger_TraA; outer membrane exchange protein TraA
    Nucleotide Protein
    Heading Accession and Version

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