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    ALOX5 arachidonate 5-lipoxygenase [ Canis lupus familiaris (dog) ]

    Gene ID: 477753, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ALOX5provided by VGNC
    Official Full Name
    arachidonate 5-lipoxygenaseprovided by VGNC
    Primary source
    VGNC:VGNC:37813
    See related
    Ensembl:ENSCAFG00845026331
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See ALOX5 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 28 NC_051832.1 (2349844..2407164, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 28 NC_006610.4 (2405370..2462571, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 28 NC_049249.1 (2315780..2373040, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 28 NC_049288.1 (2147070..2204281, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 28 NC_049769.1 (2183953..2241179, complement)

    Chromosome 28 - NC_051832.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger AN1-type containing 4 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene olfactory receptor family 13 subfamily A member 1 Neighboring gene olfactory receptor family 6 subfamily D member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and antibody recognition analysis of the canine 5-lipoxygenase gene. Loftus JP, et al. Vet Immunol Immunopathol, 2011 Aug 15. PMID 21616545
    2. Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Lascelles BD, et al. J Orthop Res, 2009 Sep. PMID 19274754
    3. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. Flamand N, et al. J Biol Chem, 2009 Jan 2. PMID 18978352, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There was no significant difference in COX-1 or LOX protein in osteoarthritis hip joints
      Title: Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis.
    2. nuclear import, which is regulated by phosphorylation on Ser-523, to determine the subcellular distribution of 5-LO, which in turn regulates leukotriene biosynthesis.
      Title: Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables arachidonate 5-lipoxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in linoleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid oxidation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polyunsaturated fatty acid 5-lipoxygenase
    NP_001192042.1
    XP_038295557.1
    XP_038295558.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205113.1 → NP_001192042.1  polyunsaturated fatty acid 5-lipoxygenase

      See identical proteins and their annotated locations for NP_001192042.1

      Status: PROVISIONAL

      Source sequence(s)
      HQ657323
      UniProtKB/TrEMBL
      A0A8C0NZM6, A0A8P0TP16, E7ECW0
      Related
      ENSCAFP00845036492.1, ENSCAFT00845046482.1
      Conserved Domains (2) summary
      cd01753
      Location:2 → 115
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:227 → 667
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051832.1 Reference ROS_Cfam_1.0

      Range
      2349844..2407164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038439629.1 → XP_038295557.1  polyunsaturated fatty acid 5-lipoxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8C0NZM6, A0A8P0TP16
      Conserved Domains (2) summary
      pfam00305
      Location:183 → 621
      Lipoxygenase
      cl00011
      Location:2 → 79
      PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...

    2. XM_038439630.1 → XP_038295558.1  polyunsaturated fatty acid 5-lipoxygenase isoform X2

      UniProtKB/TrEMBL
      A0A8C0NZM6, A0A8P0TP16
      Conserved Domains (1) summary
      pfam00305
      Location:115 → 553
      Lipoxygenase

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049288.1 Alternate UMICH_Zoey_3.1

      Range
      2147070..2204281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049769.1 Alternate UNSW_CanFamBas_1.0

      Range
      2183953..2241179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049249.1 Alternate UU_Cfam_GSD_1.0

      Range
      2315780..2373040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      2405370..2462571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials