SIRT4 sirtuin 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SIRT4provided by VGNC
Official Full Name: sirtuin 4provided by VGNC
Primary source: VGNC:VGNC:46185
See related: Ensembl:ENSCAFG00845029659
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	26	NC_051830.1 (16491640..16514126)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	26	NC_006608.4 (16228030..16250502)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	26	NC_049247.1 (16570700..16593194)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	26	NC_049286.1 (16452385..16475012)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	26	NC_049767.1 (16529465..16551725)

Chromosome 26 - NC_051830.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXO transcription factors mediate pro-apoptotic effects of CCoV-II, in part due to activation of extrinsic apoptosis pathway, while some Sirtuin family members (such as SIRT3 and SIRT4) may be involved in intrinsic apoptotic pathway
Title: Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051830.1 Reference ROS_Cfam_1.0

Range

16491640..16514126

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038436910.1 → XP_038292838.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8C0PAR8, A0A8C0T8G6

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038436909.1 → XP_038292837.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8C0PAR8, A0A8C0T8G6

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038436912.1 → XP_038292840.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A8C0PAR8

Conserved Domains (1) summary

cl00195
Location:45 → 297

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038436913.1 → XP_038292841.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

Conserved Domains (1) summary

cl00195
Location:45 → 249

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038436911.1 → XP_038292839.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8C0L8F3, A0A8C0T5A7, A0A8I3SCE0

Related

ENSCAFP00845041207.1, ENSCAFT00845052517.1

Conserved Domains (1) summary

cd01409
Location:45 → 306

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038436914.1 → XP_038292842.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

Conserved Domains (1) summary

cl00195
Location:45 → 215

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049286.1 Alternate UMICH_Zoey_3.1

Range

16452385..16475012

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038511802.1 → XP_038367730.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038511801.1 → XP_038367729.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038511804.1 → XP_038367732.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X3

Conserved Domains (1) summary

cl00195
Location:45 → 297

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038511805.1 → XP_038367733.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

Conserved Domains (1) summary

cl00195
Location:45 → 249

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038511803.1 → XP_038367731.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

Conserved Domains (1) summary

cd01409
Location:45 → 306

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038511806.1 → XP_038367734.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

Conserved Domains (1) summary

cl00195
Location:45 → 215

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049767.1 Alternate UNSW_CanFamBas_1.0

Range

16529465..16551725

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038639488.1 → XP_038495416.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038639487.1 → XP_038495415.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038639490.1 → XP_038495418.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X3

Conserved Domains (1) summary

cl00195
Location:45 → 297

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038639491.1 → XP_038495419.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

Conserved Domains (1) summary

cl00195
Location:45 → 249

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038639489.1 → XP_038495417.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

Conserved Domains (1) summary

cd01409
Location:45 → 306

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038639492.1 → XP_038495420.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

Conserved Domains (1) summary

cl00195
Location:45 → 215

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049247.1 Alternate UU_Cfam_GSD_1.0

Range

16570700..16593194

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038575300.1 → XP_038431228.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8C0PAR8, A0A8C0T8G6

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038575299.1 → XP_038431227.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8C0PAR8, A0A8C0T8G6

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038575302.1 → XP_038431230.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A8C0PAR8

Conserved Domains (1) summary

cl00195
Location:45 → 297

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038575303.1 → XP_038431231.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

Conserved Domains (1) summary

cl00195
Location:45 → 249

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038575301.1 → XP_038431229.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8C0L8F3, A0A8C0T5A7, A0A8I3SCE0

Conserved Domains (1) summary

cd01409
Location:45 → 306

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038575304.1 → XP_038431232.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

Conserved Domains (1) summary

cl00195
Location:45 → 215

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

16228030..16250502

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038459460.1 → XP_038315388.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8C0PAR8, A0A8C0T8G6

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_005636298.4 → XP_005636355.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8C0PAR8, A0A8C0T8G6

Conserved Domains (1) summary

cd01409
Location:45 → 339

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_005636299.4 → XP_005636356.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A8C0PAR8

Conserved Domains (1) summary

cl00195
Location:45 → 297

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_005636301.4 → XP_005636358.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

Conserved Domains (1) summary

cl00195
Location:45 → 249

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_858071.6 → XP_863164.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8C0L8F3, A0A8C0T5A7, A0A8I3SCE0

Conserved Domains (1) summary

cd01409
Location:45 → 306

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_038459461.1 → XP_038315389.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

Conserved Domains (1) summary

cl00195
Location:45 → 215

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...