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    HLTF helicase like transcription factor [ Canis lupus familiaris (dog) ]

    Gene ID: 477106, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HLTFprovided by VGNC
    Official Full Name
    helicase like transcription factorprovided by VGNC
    Primary source
    VGNC:VGNC:50301
    See related
    Ensembl:ENSCAFG00845022829
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See HLTF in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (44498185..44547255, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (43734282..43783354, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (44389026..44438712, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (44086465..44136026, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (44134925..44184505, complement)

    Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102153543 Neighboring gene glycogenin 1 Neighboring gene 60S ribosomal protein L15-like Neighboring gene HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene ceruloplasmin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    helicase-like transcription factor
    XP_005634612.1
    XP_013962090.1
    XP_013962091.1
    XP_013962092.1
    XP_013962093.1
    XP_013962094.1
    XP_038288551.1
    XP_038288552.1
    XP_038288553.1
    XP_038288554.1
    XP_038288555.1
    XP_038288556.1
    XP_038363847.1
    XP_038363848.1
    XP_038363849.1
    XP_038363850.1
    XP_038363851.1
    XP_038363852.1
    XP_038427090.1
    XP_038427091.1
    XP_038427092.1
    XP_038427093.1
    XP_038427094.1
    XP_038427095.1
    XP_038491281.1
    XP_038491282.1
    XP_038491283.1
    XP_038491284.1
    XP_038491285.1
    XP_038491286.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051827.1 Reference ROS_Cfam_1.0

      Range
      44498185..44547255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038432628.1 → XP_038288556.1  helicase-like transcription factor isoform X4

      UniProtKB/TrEMBL
      A0A8I3PQF2
      Conserved Domains (5) summary
      COG0553
      Location:450 → 1006
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:757 → 794
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 641
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:756 → 805
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_038432626.1 → XP_038288554.1  helicase-like transcription factor isoform X2

      UniProtKB/TrEMBL
      A0A8I3PQF2
      Conserved Domains (5) summary
      COG0553
      Location:450 → 1010
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:761 → 798
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 641
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:760 → 809
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_038432627.1 → XP_038288555.1  helicase-like transcription factor isoform X3

      UniProtKB/TrEMBL
      A0A8I3PQF2
      Conserved Domains (5) summary
      COG0553
      Location:451 → 1007
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:758 → 795
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 642
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:757 → 806
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_038432625.1 → XP_038288553.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8I3PQF2
      Conserved Domains (5) summary
      COG0553
      Location:451 → 1011
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:762 → 799
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 642
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:761 → 810
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    5. XM_038432624.1 → XP_038288552.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8I3PQF2
      Related
      ENSCAFP00845031587.1, ENSCAFT00845040331.1
      Conserved Domains (5) summary
      COG0553
      Location:451 → 1011
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:762 → 799
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 642
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:761 → 810
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    6. XM_038432623.1 → XP_038288551.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8I3PQF2
      Conserved Domains (5) summary
      COG0553
      Location:451 → 1011
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:762 → 799
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 642
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:761 → 810
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049283.1 Alternate UMICH_Zoey_3.1

      Range
      44086465..44136026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038507924.1 → XP_038363852.1  helicase-like transcription factor isoform X4

      Conserved Domains (5) summary
      COG0553
      Location:450 → 1006
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:757 → 794
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 641
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:756 → 805
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_038507922.1 → XP_038363850.1  helicase-like transcription factor isoform X2

    3. XM_038507923.1 → XP_038363851.1  helicase-like transcription factor isoform X3

      Conserved Domains (5) summary
      COG0553
      Location:451 → 1007
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:758 → 795
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 642
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:757 → 806
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_038507921.1 → XP_038363849.1  helicase-like transcription factor isoform X1

    5. XM_038507920.1 → XP_038363848.1  helicase-like transcription factor isoform X1

    6. XM_038507919.1 → XP_038363847.1  helicase-like transcription factor isoform X1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

      Range
      44134925..44184505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038635358.1 → XP_038491286.1  helicase-like transcription factor isoform X4

      Conserved Domains (5) summary
      COG0553
      Location:450 → 1006
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:757 → 794
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 641
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:756 → 805
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_038635356.1 → XP_038491284.1  helicase-like transcription factor isoform X2

    3. XM_038635357.1 → XP_038491285.1  helicase-like transcription factor isoform X3

      Conserved Domains (5) summary
      COG0553
      Location:451 → 1007
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:758 → 795
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 642
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:757 → 806
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_038635355.1 → XP_038491283.1  helicase-like transcription factor isoform X1

    5. XM_038635354.1 → XP_038491282.1  helicase-like transcription factor isoform X1

    6. XM_038635353.1 → XP_038491281.1  helicase-like transcription factor isoform X1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

      Range
      44389026..44438712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038571167.1 → XP_038427095.1  helicase-like transcription factor isoform X4

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3
      Conserved Domains (5) summary
      COG0553
      Location:450 → 1006
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:757 → 794
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 641
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:756 → 805
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_038571165.1 → XP_038427093.1  helicase-like transcription factor isoform X2

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3

    3. XM_038571166.1 → XP_038427094.1  helicase-like transcription factor isoform X3

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3
      Conserved Domains (5) summary
      COG0553
      Location:451 → 1007
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:758 → 795
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 642
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:757 → 806
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_038571164.1 → XP_038427092.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3

    5. XM_038571163.1 → XP_038427091.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3

    6. XM_038571162.1 → XP_038427090.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      43734282..43783354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005634555.4 → XP_005634612.1  helicase-like transcription factor isoform X4

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3
      Conserved Domains (5) summary
      COG0553
      Location:450 → 1006
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:757 → 794
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 641
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:756 → 805
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_014106618.3 → XP_013962093.1  helicase-like transcription factor isoform X2

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3
      Conserved Domains (4) summary
      smart00487
      Location:238 → 356
      DEXDc; DEAD-like helicases superfamily
      COG0553
      Location:450 → 1010
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:760 → 809
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_014106619.3 → XP_013962094.1  helicase-like transcription factor isoform X3

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3
      Conserved Domains (5) summary
      COG0553
      Location:451 → 1007
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:758 → 795
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      cd18071
      Location:240 → 642
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:757 → 806
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_014106617.3 → XP_013962092.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3
      Conserved Domains (4) summary
      smart00487
      Location:238 → 356
      DEXDc; DEAD-like helicases superfamily
      COG0553
      Location:451 → 1011
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:761 → 810
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    5. XM_014106616.3 → XP_013962091.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3
      Conserved Domains (4) summary
      smart00487
      Location:238 → 356
      DEXDc; DEAD-like helicases superfamily
      COG0553
      Location:451 → 1011
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:761 → 810
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    6. XM_014106615.3 → XP_013962090.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8C0MY05, A0A8P0SDB3
      Conserved Domains (4) summary
      smart00487
      Location:238 → 356
      DEXDc; DEAD-like helicases superfamily
      COG0553
      Location:451 → 1011
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain
      cl17238
      Location:761 → 810
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
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