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    DAG1 dystroglycan 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 476623, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DAG1provided by VGNC
    Official Full Name
    dystroglycan 1provided by VGNC
    Primary source
    VGNC:VGNC:39763
    See related
    Ensembl:ENSCAFG00845025980
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See DAG1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (40064114..40135683, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (39627718..39697490, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (40115684..40185987, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (39432635..39502839, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (39836035..39906605, complement)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene acylaminoacyl-peptide hydrolase Neighboring gene bassoon presynaptic cytomatrix protein Neighboring gene uncharacterized LOC111091329 Neighboring gene uncharacterized LOC119864692 Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit Neighboring gene aminomethyltransferase Neighboring gene T cell leukemia translocation altered

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic organization of the dog dystroglycan gene DAG1 locus on chromosome 20q15.1-q15.2. Leeb T, et al. Genome Res, 2000 Mar. PMID 10720570, Free PMC Article
    2. Two highly polymorphic microsatellites between the canine DAG1 and BSN genes on CFA20q15.1-15.2. Leeb T, et al. Anim Genet, 2000 Oct. PMID 11105220
    3. Genomic structures and sequences of two closely linked genes (AMT, TCTA) on dog chromosome 20q15.1-->q15.2. Leeb T, et al. Cytogenet Cell Genet, 2000. PMID 10894947
    4. Partial cloning and assignment of the canine bassoon gene (BSN) to chromosome 20q15.1-->q15.2. Leeb T, et al. Cytogenet Cell Genet, 1999. PMID 10575237
    5. Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein. Backofen B, et al. Eur J Biochem, 2002 Nov. PMID 12392556

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle attachment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of dystroglycan complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of dystrophin-associated glycoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dystroglycan 1; dystroglycan
    Names
    dystrophin-associated glycoprotein 1
    glycine cleavage system T-protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033992.1 → NP_001029164.1  dystroglycan 1 precursor

      See identical proteins and their annotated locations for NP_001029164.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ012166
      UniProtKB/Swiss-Prot
      Q9TSZ6
      UniProtKB/TrEMBL
      A0A8C0L9Q8
      Related
      ENSCAFP00845035994.1, ENSCAFT00845045847.1
      Conserved Domains (4) summary
      cd11303
      Location:59 → 160
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:300 → 401
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:603 → 892
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:179 → 301
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      40064114..40135683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038426429.1 → XP_038282357.1  dystroglycan isoform X1

      UniProtKB/Swiss-Prot
      Q9TSZ6
      UniProtKB/TrEMBL
      A0A8C0L9Q8
      Conserved Domains (4) summary
      cd11303
      Location:59 → 160
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:300 → 401
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:603 → 892
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:179 → 301
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

    2. XM_038426428.1 → XP_038282356.1  dystroglycan isoform X1

      UniProtKB/Swiss-Prot
      Q9TSZ6
      UniProtKB/TrEMBL
      A0A8C0L9Q8
      Conserved Domains (4) summary
      cd11303
      Location:59 → 160
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:300 → 401
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:603 → 892
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:179 → 301
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

    3. XM_038426431.1 → XP_038282359.1  dystroglycan isoform X1

      UniProtKB/Swiss-Prot
      Q9TSZ6
      UniProtKB/TrEMBL
      A0A8C0L9Q8
      Conserved Domains (4) summary
      cd11303
      Location:59 → 160
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:300 → 401
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:603 → 892
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:179 → 301
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

    4. XM_038426432.1 → XP_038282360.1  dystroglycan isoform X1

      UniProtKB/Swiss-Prot
      Q9TSZ6
      UniProtKB/TrEMBL
      A0A8C0L9Q8
      Conserved Domains (4) summary
      cd11303
      Location:59 → 160
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:300 → 401
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:603 → 892
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:179 → 301
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

    5. XM_038426430.1 → XP_038282358.1  dystroglycan isoform X1

      UniProtKB/Swiss-Prot
      Q9TSZ6
      UniProtKB/TrEMBL
      A0A8C0L9Q8
      Conserved Domains (4) summary
      cd11303
      Location:59 → 160
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:300 → 401
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:603 → 892
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:179 → 301
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

    6. XM_038426433.1 → XP_038282361.1  dystroglycan isoform X2

      UniProtKB/TrEMBL
      A0A8C0Z1R1
      Conserved Domains (4) summary
      cd11303
      Location:428 → 532
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:233 → 334
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:536 → 825
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:112 → 234
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      39432635..39502839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      39836035..39906605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      40115684..40185987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      39627718..39697490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TSZ6.1 GenPept UniProtKB/Swiss-Prot:Q9TSZ6

    Gene LinkOut

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