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    PAH phenylalanine hydroxylase [ Canis lupus familiaris (dog) ]

    Gene ID: 475446, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PAHprovided by VGNC
    Official Full Name
    phenylalanine hydroxylaseprovided by VGNC
    Primary source
    VGNC:VGNC:54218
    See related
    Ensembl:ENSCAFG00845009553
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PAH in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (42245356..42325951, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (41957869..42038236, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (41882259..41962824, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (41514955..41595406, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (41612701..41693246, complement)

    Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090067 Neighboring gene insulin like growth factor 1 Neighboring gene uncharacterized LOC119869366 Neighboring gene uncharacterized LOC119869373 Neighboring gene achaete-scute family bHLH transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phenylalanine 4-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tyrosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenylalanine-4-hydroxylase
    XP_038352393.1
    XP_038414790.1
    XP_038478712.1
    XP_038544383.1
    XP_532671.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051819.1 Reference ROS_Cfam_1.0

      Range
      42245356..42325951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038688455.1 → XP_038544383.1  phenylalanine-4-hydroxylase

      UniProtKB/TrEMBL
      A0A8C0LPC7
      Related
      ENSCAFP00845013087.1, ENSCAFT00845016828.1
      Conserved Domains (1) summary
      TIGR01268
      Location:19 → 451
      Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049275.1 Alternate UMICH_Zoey_3.1

      Range
      41514955..41595406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038496465.1 → XP_038352393.1  phenylalanine-4-hydroxylase

      Conserved Domains (1) summary
      TIGR01268
      Location:19 → 451
      Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

      Range
      41612701..41693246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038622784.1 → XP_038478712.1  phenylalanine-4-hydroxylase

      Conserved Domains (1) summary
      TIGR01268
      Location:19 → 451
      Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

      Range
      41882259..41962824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038558862.1 → XP_038414790.1  phenylalanine-4-hydroxylase

      UniProtKB/TrEMBL
      A0A8C0LPC7
      Conserved Domains (1) summary
      TIGR01268
      Location:19 → 451
      Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      41957869..42038236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_532671.7 → XP_532671.3  phenylalanine-4-hydroxylase

      UniProtKB/TrEMBL
      A0A8C0LPC7
      Conserved Domains (1) summary
      TIGR01268
      Location:19 → 451
      Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
    Nucleotide Protein
    Heading Accession and Version

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