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    PON1 paraoxonase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 475234, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PON1provided by VGNC
    Official Full Name
    paraoxonase 1provided by VGNC
    Primary source
    VGNC:VGNC:44812
    See related
    Ensembl:ENSCAFG00845020626
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PON1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 14 NC_051818.1 (20388041..20423054, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 14 NC_006596.4 (20124634..20159679, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 14 NC_049235.1 (20525175..20560208, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 14 NC_049274.1 (20532696..20567711, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 14 NC_049755.1 (20267821..20302851, complement)

    Chromosome 14 - NC_051818.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 9A Neighboring gene U6 spliceosomal RNA Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene paraoxonase 3 Neighboring gene paraoxonase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Paraoxonase activity as a tool for clinical monitoring of dogs treated for canine leishmaniasis. Rossi G, et al. Vet J, 2014 Jan. PMID 24188864
    2. The diagnostic and prognostic value of paraoxonase-1 and butyrylcholinesterase activities compared with acute-phase proteins in septic dogs and stratified by the acute patient physiologic and laboratory evaluation score. Torrente C, et al. Vet Clin Pathol, 2019 Dec. PMID 31789474

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the diagnostic and prognostic value of PON-1 and BChE in septic dogs
      Title: The diagnostic and prognostic value of paraoxonase-1 and butyrylcholinesterase activities compared with acute-phase proteins in septic dogs and stratified by the acute patient physiologic and laboratory evaluation score.
    2. The activity of PON1 as a marker for clinical response in dogs treated for leishmaniasis is reported.
      Title: Paraoxonase activity as a tool for clinical monitoring of dogs treated for canine leishmaniasis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aryldialkylphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables arylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serum paraoxonase/arylesterase 1
    XP_038350505.1
    XP_038412790.1
    XP_038476729.1
    XP_038542419.1
    XP_850219.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051818.1 Reference ROS_Cfam_1.0

      Range
      20388041..20423054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038686491.1 → XP_038542419.1  serum paraoxonase/arylesterase 1

      UniProtKB/TrEMBL
      A0A8C0KAZ8, A0A8C0NUH5, A0A8I3PDF6
      Related
      ENSCAFP00845028455.1, ENSCAFT00845036355.1
      Conserved Domains (2) summary
      pfam01731
      Location:168 → 253
      Arylesterase
      pfam08450
      Location:211 → 307
      SGL; SMP-30/Gluconolaconase/LRE-like region

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049274.1 Alternate UMICH_Zoey_3.1

      Range
      20532696..20567711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038494577.1 → XP_038350505.1  serum paraoxonase/arylesterase 1

      Conserved Domains (2) summary
      pfam01731
      Location:168 → 253
      Arylesterase
      pfam08450
      Location:211 → 307
      SGL; SMP-30/Gluconolaconase/LRE-like region

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049755.1 Alternate UNSW_CanFamBas_1.0

      Range
      20267821..20302851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038620801.1 → XP_038476729.1  serum paraoxonase/arylesterase 1

      Conserved Domains (2) summary
      pfam01731
      Location:168 → 253
      Arylesterase
      pfam08450
      Location:211 → 307
      SGL; SMP-30/Gluconolaconase/LRE-like region

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049235.1 Alternate UU_Cfam_GSD_1.0

      Range
      20525175..20560208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038556862.1 → XP_038412790.1  serum paraoxonase/arylesterase 1

      UniProtKB/TrEMBL
      A0A8C0KAZ8, A0A8C0NUH5, A0A8I3PDF6
      Conserved Domains (2) summary
      pfam01731
      Location:168 → 253
      Arylesterase
      pfam08450
      Location:211 → 307
      SGL; SMP-30/Gluconolaconase/LRE-like region

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      20124634..20159679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_845126.6 → XP_850219.2  serum paraoxonase/arylesterase 1

      UniProtKB/TrEMBL
      A0A8C0KAZ8, A0A8P0S812
      Conserved Domains (2) summary
      pfam01731
      Location:168 → 253
      Arylesterase
      pfam08450
      Location:211 → 307
      SGL; SMP-30/Gluconolaconase/LRE-like region
    Nucleotide Protein
    Heading Accession and Version

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