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    DERL1 derlin 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 475086, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DERL1provided by VGNC
    Official Full Name
    derlin 1provided by VGNC
    Primary source
    VGNC:VGNC:39902
    See related
    Ensembl:ENSCAFG00845008768
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See DERL1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 13 NC_051817.1 (21760369..21789449, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 13 NC_006595.4 (21389332..21418411, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 13 NC_049234.1 (21836798..21865874, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 13 NC_049273.1 (21488954..21517996, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 13 NC_049754.1 (21594093..21623156, complement)

    Chromosome 13 - NC_051817.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106559606 Neighboring gene uncharacterized LOC102153186 Neighboring gene zinc fingers and homeoboxes 2 Neighboring gene uncharacterized LOC102153799 Neighboring gene acyl-CoA-binding protein-like Neighboring gene TBC1 domain family member 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors. Klopfleisch R, et al. Vet Pathol, 2010 May. PMID 20375427
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the combined expression patterns of BMP2, LTBP4, and DERL1 (Derlin-1) correctly classified each individual tumor as benign or malignant.
      Title: The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables misfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-specific protease binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Hrd1p ubiquitin ligase ERAD-L complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    derlin-1
    Names
    Der1-like domain family, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051817.1 Reference ROS_Cfam_1.0

      Range
      21760369..21789449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038684935.1 → XP_038540863.1  derlin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I3N0L8, A0A8P0P8Z0
      Related
      ENSCAFP00845012147.1, ENSCAFT00845015627.1
      Conserved Domains (1) summary
      pfam04511
      Location:11 → 204
      DER1; Der1-like family

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049273.1 Alternate UMICH_Zoey_3.1

      Range
      21488954..21517996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038493158.1 → XP_038349086.1  derlin-1 isoform X1

      Conserved Domains (1) summary
      pfam04511
      Location:11 → 204
      DER1; Der1-like family

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049754.1 Alternate UNSW_CanFamBas_1.0

      Range
      21594093..21623156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038619323.1 → XP_038475251.1  derlin-1 isoform X1

      Conserved Domains (1) summary
      pfam04511
      Location:11 → 204
      DER1; Der1-like family

    2. XM_038619324.1 → XP_038475252.1  derlin-1 isoform X2

      Conserved Domains (1) summary
      cl21536
      Location:1 → 104
      Rhomboid; Rhomboid family

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049234.1 Alternate UU_Cfam_GSD_1.0

      Range
      21836798..21865874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038555429.1 → XP_038411357.1  derlin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I3N0L8, A0A8P0P8Z0
      Conserved Domains (1) summary
      pfam04511
      Location:11 → 204
      DER1; Der1-like family

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006595.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      21389332..21418411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_532320.7 → XP_532320.2  derlin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I3N0L8, A0A8P0P8Z0
      Conserved Domains (1) summary
      pfam04511
      Location:11 → 204
      DER1; Der1-like family
    Nucleotide Protein
    Heading Accession and Version

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