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    STK3 serine/threonine kinase 3 [ Canis lupus familiaris (dog) ]

    Gene ID: 475045, updated on 17-Aug-2024

    Summary

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    Official Symbol
    STK3provided by VGNC
    Official Full Name
    serine/threonine kinase 3provided by VGNC
    Primary source
    VGNC:VGNC:46911
    See related
    Ensembl:ENSCAFG00845025019
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See STK3 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 13 NC_051817.1 (796957..1172656, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 13 NC_006595.4 (640435..1015875, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 13 NC_049234.1 (753947..1129925, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 13 NC_049273.1 (639257..1015142, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 13 NC_049754.1 (747613..1123107, complement)

    Chromosome 13 - NC_051817.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111098432 Neighboring gene potassium voltage-gated channel modifier subfamily S member 2 Neighboring gene nucleophosmin-like Neighboring gene U1 small nuclear ribonucleoprotein C-like Neighboring gene U6 spliceosomal RNA Neighboring gene collagen alpha-1(I) chain-like Neighboring gene uncharacterized LOC111098487 Neighboring gene uncharacterized LOC111098488 Neighboring gene odd-skipped related transciption factor 2 Neighboring gene spliceosome-associated protein CWC15 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 3
    Names
    serine/threonine kinase 3 (STE20 homolog, yeast)
    XP_022282263.1
    XP_038348809.1
    XP_038348810.1
    XP_038348811.1
    XP_038348812.1
    XP_038348813.1
    XP_038348815.1
    XP_038348816.1
    XP_038411080.1
    XP_038411081.1
    XP_038411082.1
    XP_038411083.1
    XP_038411084.1
    XP_038411085.1
    XP_038411086.1
    XP_038474970.1
    XP_038474971.1
    XP_038474972.1
    XP_038474973.1
    XP_038474974.1
    XP_038474975.1
    XP_038474976.1
    XP_038540592.1
    XP_038540593.1
    XP_038540594.1
    XP_038540595.1
    XP_038540596.1
    XP_038540597.1
    XP_038540598.1
    XP_038544375.1
    XP_038544381.1
    XP_038544382.1
    XP_038544389.1
    XP_038544392.1
    XP_532280.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051817.1 Reference ROS_Cfam_1.0

      Range
      796957..1172656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038684669.1 → XP_038540597.1  serine/threonine-protein kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW30
      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    2. XM_038684668.1 → XP_038540596.1  serine/threonine-protein kinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8C0NW30
      Conserved Domains (2) summary
      cd06612
      Location:8 → 208
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:367 → 414
      Mst1_SARAH; C terminal SARAH domain of Mst1

    3. XM_038684666.1 → XP_038540594.1  serine/threonine-protein kinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0NW30, A0A8I3PXE7, A0A8P0TEQ0
      Related
      ENSCAFP00845034623.1, ENSCAFT00845044183.1
      Conserved Domains (2) summary
      cd06612
      Location:10 → 251
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:410 → 457
      Mst1_SARAH; C terminal SARAH domain of Mst1

    4. XM_038684667.1 → XP_038540595.1  serine/threonine-protein kinase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NJP1, A0A8C0NW30, A0A8I3PPW5
      Related
      ENSCAFP00845034806.1, ENSCAFT00845044417.1
      Conserved Domains (2) summary
      cd06612
      Location:23 → 235
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:394 → 441
      Mst1_SARAH; C terminal SARAH domain of Mst1

    5. XM_038684664.1 → XP_038540592.1  serine/threonine-protein kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LN56, A0A8C0NW30, A0A8C0SHB4, A0A8I3PTK7
      Related
      ENSCAFP00845034733.1, ENSCAFT00845044328.1
      Conserved Domains (2) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:437 → 484
      Mst1_SARAH; C terminal SARAH domain of Mst1

    6. XM_038684670.1 → XP_038540598.1  serine/threonine-protein kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW30
      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    7. XM_038684665.1 → XP_038540593.1  serine/threonine-protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NW30, A0A8C0YXQ6, A0A8I3Q6G4
      Related
      ENSCAFP00845034956.1, ENSCAFT00845044617.1
      Conserved Domains (1) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049273.1 Alternate UMICH_Zoey_3.1

      Range
      639257..1015142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038492887.1 → XP_038348815.1  serine/threonine-protein kinase 3 isoform X6

      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    2. XM_038492885.1 → XP_038348813.1  serine/threonine-protein kinase 3 isoform X5

      Conserved Domains (2) summary
      cd06612
      Location:8 → 208
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:367 → 414
      Mst1_SARAH; C terminal SARAH domain of Mst1

    3. XM_038492883.1 → XP_038348811.1  serine/threonine-protein kinase 3 isoform X3

      Conserved Domains (2) summary
      cd06612
      Location:10 → 251
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:410 → 457
      Mst1_SARAH; C terminal SARAH domain of Mst1

    4. XM_038492884.1 → XP_038348812.1  serine/threonine-protein kinase 3 isoform X4

      Conserved Domains (2) summary
      cd06612
      Location:23 → 235
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:394 → 441
      Mst1_SARAH; C terminal SARAH domain of Mst1

    5. XM_038492881.1 → XP_038348809.1  serine/threonine-protein kinase 3 isoform X1

      Conserved Domains (2) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:437 → 484
      Mst1_SARAH; C terminal SARAH domain of Mst1

    6. XM_038492888.1 → XP_038348816.1  serine/threonine-protein kinase 3 isoform X6

      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    7. XM_038492882.1 → XP_038348810.1  serine/threonine-protein kinase 3 isoform X2

      Conserved Domains (1) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049754.1 Alternate UNSW_CanFamBas_1.0

      Range
      747613..1123107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038619047.1 → XP_038474975.1  serine/threonine-protein kinase 3 isoform X6

      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    2. XM_038619046.1 → XP_038474974.1  serine/threonine-protein kinase 3 isoform X5

      Conserved Domains (2) summary
      cd06612
      Location:8 → 208
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:367 → 414
      Mst1_SARAH; C terminal SARAH domain of Mst1

    3. XM_038619044.1 → XP_038474972.1  serine/threonine-protein kinase 3 isoform X3

      Conserved Domains (2) summary
      cd06612
      Location:10 → 251
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:410 → 457
      Mst1_SARAH; C terminal SARAH domain of Mst1

    4. XM_038619045.1 → XP_038474973.1  serine/threonine-protein kinase 3 isoform X4

      Conserved Domains (2) summary
      cd06612
      Location:23 → 235
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:394 → 441
      Mst1_SARAH; C terminal SARAH domain of Mst1

    5. XM_038619042.1 → XP_038474970.1  serine/threonine-protein kinase 3 isoform X1

      Conserved Domains (2) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:437 → 484
      Mst1_SARAH; C terminal SARAH domain of Mst1

    6. XM_038619048.1 → XP_038474976.1  serine/threonine-protein kinase 3 isoform X6

      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    7. XM_038619043.1 → XP_038474971.1  serine/threonine-protein kinase 3 isoform X2

      Conserved Domains (1) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049234.1 Alternate UU_Cfam_GSD_1.0

      Range
      753947..1129925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038555157.1 → XP_038411085.1  serine/threonine-protein kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW30
      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    2. XM_038555156.1 → XP_038411084.1  serine/threonine-protein kinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8C0NW30
      Conserved Domains (2) summary
      cd06612
      Location:8 → 208
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:367 → 414
      Mst1_SARAH; C terminal SARAH domain of Mst1

    3. XM_038555154.1 → XP_038411082.1  serine/threonine-protein kinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0NW30, A0A8I3PXE7, A0A8P0TEQ0
      Conserved Domains (2) summary
      cd06612
      Location:10 → 251
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:410 → 457
      Mst1_SARAH; C terminal SARAH domain of Mst1

    4. XM_038555155.1 → XP_038411083.1  serine/threonine-protein kinase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NJP1, A0A8C0NW30, A0A8I3PPW5
      Conserved Domains (2) summary
      cd06612
      Location:23 → 235
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:394 → 441
      Mst1_SARAH; C terminal SARAH domain of Mst1

    5. XM_038555152.1 → XP_038411080.1  serine/threonine-protein kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LN56, A0A8C0NW30, A0A8C0SHB4, A0A8I3PTK7
      Conserved Domains (2) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:437 → 484
      Mst1_SARAH; C terminal SARAH domain of Mst1

    6. XM_038555158.1 → XP_038411086.1  serine/threonine-protein kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW30
      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    7. XM_038555153.1 → XP_038411081.1  serine/threonine-protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NW30, A0A8C0YXQ6, A0A8I3Q6G4
      Conserved Domains (1) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006595.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      640435..1015875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038688461.1 → XP_038544389.1  serine/threonine-protein kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW30
      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    2. XM_038688454.1 → XP_038544382.1  serine/threonine-protein kinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8C0NW30
      Conserved Domains (2) summary
      cd06612
      Location:8 → 208
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:367 → 414
      Mst1_SARAH; C terminal SARAH domain of Mst1

    3. XM_038688447.1 → XP_038544375.1  serine/threonine-protein kinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0NW30, A0A8I3PXE7, A0A8P0TEQ0
      Conserved Domains (2) summary
      cd06612
      Location:10 → 251
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:410 → 457
      Mst1_SARAH; C terminal SARAH domain of Mst1

    4. XM_038688453.1 → XP_038544381.1  serine/threonine-protein kinase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NJP1, A0A8C0NW30, A0A8I3PPW5
      Conserved Domains (2) summary
      cd06612
      Location:23 → 235
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:394 → 441
      Mst1_SARAH; C terminal SARAH domain of Mst1

    5. XM_532280.7 → XP_532280.2  serine/threonine-protein kinase 3 isoform X1

      See identical proteins and their annotated locations for XP_532280.2

      UniProtKB/TrEMBL
      A0A8C0LN56, A0A8C0NW30, A0A8C0SHB4, A0A8I3PTK7
      Conserved Domains (2) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:437 → 484
      Mst1_SARAH; C terminal SARAH domain of Mst1

    6. XM_038688464.1 → XP_038544392.1  serine/threonine-protein kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8C0NW30
      Conserved Domains (2) summary
      cd06612
      Location:1 → 205
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:364 → 411
      Mst1_SARAH; C terminal SARAH domain of Mst1

    7. XM_022426555.2 → XP_022282263.1  serine/threonine-protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NW30, A0A8C0YXQ6, A0A8I3Q6G4
      Conserved Domains (1) summary
      cd06612
      Location:23 → 278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    Nucleotide Protein
    Heading Accession and Version

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