FYN FYN proto-oncogene, Src family tyrosine kinase [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: FYNprovided by VGNC
Official Full Name: FYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source: VGNC:VGNC:41027
See related: Ensembl:ENSCAFG00845017640
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	12	NC_051816.1 (68986784..69198525, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	12	NC_006594.4 (67924675..68136151, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	12	NC_049233.1 (68510644..68722405, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	12	NC_049272.1 (68338226..68549311, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	12	NC_049753.1 (68184783..68396306, complement)

Chromosome 12 - NC_051816.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase Fyn

Names: FYN oncogene related to SRC, FGR, YES

XP_005627776.1

EC 2.7.10.2

XP_038348587.1

EC 2.7.10.2

XP_038348589.1

EC 2.7.10.2

XP_038348590.1

EC 2.7.10.2

XP_038410908.1

EC 2.7.10.2

XP_038410909.1

EC 2.7.10.2

XP_038410910.1

EC 2.7.10.2

XP_038474775.1

EC 2.7.10.2

XP_038474776.1

EC 2.7.10.2

XP_038474777.1

EC 2.7.10.2

XP_038529477.1

EC 2.7.10.2

XP_038540327.1

EC 2.7.10.2

XP_038540328.1

EC 2.7.10.2

XP_038540329.1

EC 2.7.10.2

XP_854467.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051816.1 Reference ROS_Cfam_1.0

Range

68986784..69198525 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038684401.1 → XP_038540329.1 tyrosine-protein kinase Fyn isoform X2

UniProtKB/TrEMBL

A0A8C0MFP4, A0A8C0S435, A0A8I3P3X1, A0A8I3S2Y2

Related

ENSCAFP00845024839.1, ENSCAFT00845031738.1

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_038684399.1 → XP_038540327.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/TrEMBL

A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3

Related

ENSCAFP00845024737.1, ENSCAFT00845031600.1

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_038684400.1 → XP_038540328.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/TrEMBL

A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

Alternate UMICH_Zoey_3.1

Genomic

NC_049272.1 Alternate UMICH_Zoey_3.1

Range

68338226..68549311 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038492662.1 → XP_038348590.1 tyrosine-protein kinase Fyn isoform X2

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_038492659.1 → XP_038348587.1 tyrosine-protein kinase Fyn isoform X1

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_038492661.1 → XP_038348589.1 tyrosine-protein kinase Fyn isoform X1

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049753.1 Alternate UNSW_CanFamBas_1.0

Range

68184783..68396306 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038618849.1 → XP_038474777.1 tyrosine-protein kinase Fyn isoform X2

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_038618847.1 → XP_038474775.1 tyrosine-protein kinase Fyn isoform X1

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_038618848.1 → XP_038474776.1 tyrosine-protein kinase Fyn isoform X1

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049233.1 Alternate UU_Cfam_GSD_1.0

Range

68510644..68722405 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038554982.1 → XP_038410910.1 tyrosine-protein kinase Fyn isoform X2

UniProtKB/TrEMBL

A0A8C0MFP4, A0A8C0S435, A0A8I3P3X1, A0A8I3S2Y2

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_038554980.1 → XP_038410908.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/TrEMBL

A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_038554981.1 → XP_038410909.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/TrEMBL

A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

67924675..68136151 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005627719.3 → XP_005627776.1 tyrosine-protein kinase Fyn isoform X2

UniProtKB/TrEMBL

A0A8C0MFP4, A0A8C0S435, A0A8I3P3X1, A0A8I3S2Y2

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_849374.5 → XP_854467.1 tyrosine-protein kinase Fyn isoform X1

See identical proteins and their annotated locations for XP_854467.1

UniProtKB/TrEMBL

A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_038673549.1 → XP_038529477.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/TrEMBL

A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn