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    DRD3 dopamine receptor D3 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 470885, updated on 10-Oct-2024

    Summary

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    Official Symbol
    DRD3provided by VGNC
    Official Full Name
    dopamine receptor D3provided by VGNC
    Primary source
    VGNC:VGNC:1797
    Locus tag
    CK820_G0023826
    See related
    Ensembl:ENSPTRG00000015241
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See DRD3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 2 NC_086015.1 (117453460..117525059, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 3 NC_072401.1 (117362837..117434437, complement)

    Chromosome 2 - NC_086015.1Genomic Context describing neighboring genes Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2 Neighboring gene histone H2B type 1-K-like Neighboring gene atos homolog protein B-like Neighboring gene zinc finger protein 80

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phospholipase C-activating dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D(3) dopamine receptor
    Names
    dopamine D3 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033912.1 → NP_001029084.1  D(3) dopamine receptor

      See identical proteins and their annotated locations for NP_001029084.1

      Status: PROVISIONAL

      Source sequence(s)
      AY665256
      UniProtKB/Swiss-Prot
      Q5IS72
      UniProtKB/TrEMBL
      A0A2J8M388, A0A2J8M392, A0A2K6HKH4, A0A6D2Y196
      Related
      ENSPTRP00000026285.5, ENSPTRT00000028481.5
      Conserved Domains (1) summary
      cd15310
      Location:30 → 394
      7tmA_D3_dopamine_R; D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      117453460..117525059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054680310.2 → XP_054536285.1  D(3) dopamine receptor isoform X1

    2. XM_054680311.2 → XP_054536286.1  D(3) dopamine receptor isoform X2

    3. XM_054680309.2 → XP_054536284.1  D(3) dopamine receptor isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5IS72.1 GenPept UniProtKB/Swiss-Prot:Q5IS72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials