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    ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 457410, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ARHGEF11provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 11provided by VGNC
    Primary source
    VGNC:VGNC:6718
    Locus tag
    CK820_G0041340
    See related
    Ensembl:ENSPTRG00000024318
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF11 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 1 NC_072398.2 (92153116..92265190)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (139084547..139196617, complement)

    Chromosome 1 - NC_072398.2Genomic Context describing neighboring genes Neighboring gene WD40 repeat-containing protein SMU1-like Neighboring gene uncharacterized LOC107974098 Neighboring gene microRNA mir-765 Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 11
    Names
    Rho guanine nucleotide exchange factor (GEF) 11

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      92153116..92265190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016929637.4 → XP_016785126.1  rho guanine nucleotide exchange factor 11 isoform X11

      UniProtKB/TrEMBL
      A0A2I3S6L6
      Related
      ENSPTRP00000072202.1

    2. XM_063796612.1 → XP_063652682.1  rho guanine nucleotide exchange factor 11 isoform X12

    3. XM_016929602.4 → XP_016785091.1  rho guanine nucleotide exchange factor 11 isoform X3

      UniProtKB/TrEMBL
      A0A2I3S6L6

    4. XM_016929611.4 → XP_016785100.1  rho guanine nucleotide exchange factor 11 isoform X5

      UniProtKB/TrEMBL
      A0A2I3S6L6

    5. XM_513900.8 → XP_513900.2  rho guanine nucleotide exchange factor 11 isoform X10

      See identical proteins and their annotated locations for XP_513900.2

      UniProtKB/TrEMBL
      A0A2I3S6L6, A0A2I3TPR1, A0A2J8K5I0, A0A6D2X935
      Related
      ENSPTRP00000091210.1
      Conserved Domains (5) summary
      cd08753
      Location:330 → 474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      cd00160
      Location:775 → 961
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:979 → 1121
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      cl28033
      Location:1239 → 1562
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    6. XM_054687039.2 → XP_054543014.1  rho guanine nucleotide exchange factor 11 isoform X14

    7. XM_001167782.7 → XP_001167782.1  rho guanine nucleotide exchange factor 11 isoform X20

      See identical proteins and their annotated locations for XP_001167782.1

      UniProtKB/TrEMBL
      A0A2I3SCP7, A0A2J8K5K9, A0A6D2VYF3, H2R0Q2, K7DQI1
      Related
      ENSPTRP00000041072.2
      Conserved Domains (5) summary
      cd08753
      Location:290 → 434
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      cd00160
      Location:735 → 921
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:939 → 1081
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      cl28033
      Location:1199 → 1522
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    8. XM_009434759.5 → XP_009433034.1  rho guanine nucleotide exchange factor 11 isoform X9

      UniProtKB/TrEMBL
      A0A2I3S6L6
      Conserved Domains (6) summary
      cd08753
      Location:330 → 474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61 → 139
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:980 → 1122
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1040 → 1120
      PH; PH domain
      pfam00621
      Location:779 → 963
      RhoGEF; RhoGEF domain

    9. XM_054687031.2 → XP_054543006.1  rho guanine nucleotide exchange factor 11 isoform X13

    10. XM_063796640.1 → XP_063652710.1  rho guanine nucleotide exchange factor 11 isoform X18

    11. XM_054687062.2 → XP_054543037.1  rho guanine nucleotide exchange factor 11 isoform X19

    12. XM_009434716.5 → XP_009432991.1  rho guanine nucleotide exchange factor 11 isoform X1

      See identical proteins and their annotated locations for XP_009432991.1

      UniProtKB/TrEMBL
      A0A2I3S6L6
      Conserved Domains (6) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:996 → 1138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1056 → 1136
      PH; PH domain
      pfam00621
      Location:795 → 979
      RhoGEF; RhoGEF domain

    13. XM_009434742.5 → XP_009433017.1  rho guanine nucleotide exchange factor 11 isoform X6

      UniProtKB/TrEMBL
      A0A2I3T0U1
      Conserved Domains (6) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:986 → 1128
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1046 → 1126
      PH; PH domain
      pfam00621
      Location:785 → 969
      RhoGEF; RhoGEF domain

    14. XM_009434731.5 → XP_009433006.1  rho guanine nucleotide exchange factor 11 isoform X2

      UniProtKB/TrEMBL
      A0A2I3S6L6
      Conserved Domains (6) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:995 → 1137
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1055 → 1135
      PH; PH domain
      pfam00621
      Location:794 → 978
      RhoGEF; RhoGEF domain

    15. XM_009434749.5 → XP_009433024.1  rho guanine nucleotide exchange factor 11 isoform X8

      UniProtKB/TrEMBL
      A0A2I3T0U1
      Conserved Domains (6) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:985 → 1127
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1045 → 1125
      PH; PH domain
      pfam00621
      Location:784 → 968
      RhoGEF; RhoGEF domain

    16. XM_009434770.5 → XP_009433045.1  rho guanine nucleotide exchange factor 11 isoform X16

      UniProtKB/TrEMBL
      A0A2I3SCP7
      Conserved Domains (6) summary
      cd08753
      Location:306 → 450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:956 → 1098
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1016 → 1096
      PH; PH domain
      pfam00621
      Location:755 → 939
      RhoGEF; RhoGEF domain

    17. XM_009434773.5 → XP_009433048.1  rho guanine nucleotide exchange factor 11 isoform X17

      UniProtKB/TrEMBL
      A0A2I3SCP7
      Conserved Domains (6) summary
      cd08753
      Location:306 → 450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:955 → 1097
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1015 → 1095
      PH; PH domain
      pfam00621
      Location:754 → 938
      RhoGEF; RhoGEF domain

    18. XM_009434735.5 → XP_009433010.1  rho guanine nucleotide exchange factor 11 isoform X4

      UniProtKB/TrEMBL
      A0A2I3S6L6
      Conserved Domains (6) summary
      cd08753
      Location:341 → 485
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:72 → 150
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:57 → 131
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:991 → 1133
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1051 → 1131
      PH; PH domain
      pfam00621
      Location:790 → 974
      RhoGEF; RhoGEF domain

    19. XM_009434753.5 → XP_009433028.1  rho guanine nucleotide exchange factor 11 isoform X7

      UniProtKB/TrEMBL
      A0A2I3S6L6
      Conserved Domains (6) summary
      cd08753
      Location:335 → 479
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:66 → 144
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:51 → 125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:985 → 1127
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1045 → 1125
      PH; PH domain
      pfam00621
      Location:784 → 968
      RhoGEF; RhoGEF domain

    20. XM_009434767.5 → XP_009433042.1  rho guanine nucleotide exchange factor 11 isoform X15

      UniProtKB/TrEMBL
      A0A2I3S6L6
      Conserved Domains (6) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:996 → 1138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1056 → 1136
      PH; PH domain
      pfam00621
      Location:795 → 979
      RhoGEF; RhoGEF domain
    Nucleotide Protein
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