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    CAPN1 calpain 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 451317, updated on 10-Oct-2024

    Summary

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    Official Symbol
    CAPN1provided by VGNC
    Official Full Name
    calpain 1provided by VGNC
    Primary source
    VGNC:VGNC:7514
    Locus tag
    CK820_G0033964
    See related
    Ensembl:ENSPTRG00000003869
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See CAPN1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 9 NC_072407.2 (67513024..67543847)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 11 NC_072409.1 (66620713..66651442)

    Chromosome 9 - NC_072407.2Genomic Context describing neighboring genes Neighboring gene HIG1 domain family member 1A, mitochondrial-like Neighboring gene U2 spliceosomal RNA Neighboring gene speedy/RINGO cell cycle regulator family member C Neighboring gene phosphoglycerate mutase 1-like Neighboring gene solute carrier family 22 member 20 Neighboring gene uncharacterized LOC134807307 Neighboring gene DNA polymerase alpha 2, accessory subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain-1 catalytic subunit
    Names
    calpain 1, (mu/I) large subunit
    XP_016776710.1
    XP_016776711.1
    XP_016776712.1
    XP_016776713.1
    XP_054518439.1
    XP_054518440.1
    XP_054518441.1
    XP_054518442.1
    XP_063639130.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072407.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      67513024..67543847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054662464.2 → XP_054518439.1  calpain-1 catalytic subunit isoform X2

    2. XM_016921223.4 → XP_016776712.1  calpain-1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A2I3RT65, A0A2J8QC43, A0A6D2VY41, H2Q425, K7CEN7
      Conserved Domains (3) summary
      cd00214
      Location:364 → 524
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16198
      Location:546 → 714
      EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease

    3. XM_054662465.2 → XP_054518440.1  calpain-1 catalytic subunit isoform X2

    4. XM_054662467.2 → XP_054518442.1  calpain-1 catalytic subunit isoform X2

    5. XM_016921221.4 → XP_016776710.1  calpain-1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A2I3RT65, A0A2J8QC43, A0A6D2VY41, H2Q425, K7CEN7
      Conserved Domains (3) summary
      cd00214
      Location:364 → 524
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16198
      Location:546 → 714
      EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease

    6. XM_063783060.1 → XP_063639130.1  calpain-1 catalytic subunit isoform X2

    7. XM_016921224.4 → XP_016776713.1  calpain-1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A2I3RT65, A0A2J8QC43, A0A6D2VY41, H2Q425, K7CEN7
      Conserved Domains (3) summary
      cd00214
      Location:364 → 524
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16198
      Location:546 → 714
      EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease

    8. XM_016921222.4 → XP_016776711.1  calpain-1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A2I3RT65, A0A2J8QC43, A0A6D2VY41, H2Q425, K7CEN7
      Conserved Domains (3) summary
      cd00214
      Location:364 → 524
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16198
      Location:546 → 714
      EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease

    9. XM_054662466.2 → XP_054518441.1  calpain-1 catalytic subunit isoform X2

    Nucleotide Protein
    Heading Accession and Version

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