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    GSS glutathione synthetase [ Canis lupus familiaris (dog) ]

    Gene ID: 442962, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GSSprovided by VGNC
    Official Full Name
    glutathione synthetaseprovided by VGNC
    Primary source
    VGNC:VGNC:41534
    See related
    Ensembl:ENSCAFG00845017262
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See GSS in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (24665657..24692375, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (23619971..23646466, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (24487171..24513688, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (23952937..23979420, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (24048251..24074736, complement)

    Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119865656 Neighboring gene gamma-glutamyltransferase 7 Neighboring gene acyl-CoA synthetase short chain family member 2 Neighboring gene ubiquitin-conjugating enzyme E2 N-like Neighboring gene myosin heavy chain 7B Neighboring gene uncharacterized LOC119865657 Neighboring gene microRNA mir-499

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glutathione binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glutathione synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione synthetase
    XP_005635021.1
    XP_013962362.1
    XP_013962363.1
    XP_038289532.1
    XP_038289533.1
    XP_038289534.1
    XP_038289535.1
    XP_038364709.1
    XP_038364710.1
    XP_038364711.1
    XP_038364712.1
    XP_038428022.1
    XP_038428023.1
    XP_038428024.1
    XP_038428025.1
    XP_038492275.1
    XP_038492276.1
    XP_038492277.1
    XP_038492278.1
    XP_851615.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051828.1 Reference ROS_Cfam_1.0

      Range
      24665657..24692375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038433604.1 → XP_038289532.1  glutathione synthetase isoform X1

      UniProtKB/TrEMBL
      A0A8C0QD92, A0A8I3NS50, A0A8I3RZR9
      Related
      ENSCAFP00845024060.1, ENSCAFT00845030666.1
      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    2. XM_038433605.1 → XP_038289533.1  glutathione synthetase isoform X1

      UniProtKB/TrEMBL
      A0A8C0QD92, A0A8I3NS50, A0A8I3RZR9
      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    3. XM_038433606.1 → XP_038289534.1  glutathione synthetase isoform X1

      UniProtKB/TrEMBL
      A0A8C0QD92, A0A8I3NS50, A0A8I3RZR9
      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    4. XM_038433607.1 → XP_038289535.1  glutathione synthetase isoform X2

      UniProtKB/TrEMBL
      A0A8I3RZR9
      Conserved Domains (1) summary
      cl00170
      Location:1 → 405
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049284.1 Alternate UMICH_Zoey_3.1

      Range
      23952937..23979420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038508781.1 → XP_038364709.1  glutathione synthetase isoform X1

      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    2. XM_038508782.1 → XP_038364710.1  glutathione synthetase isoform X1

      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    3. XM_038508783.1 → XP_038364711.1  glutathione synthetase isoform X1

      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    4. XM_038508784.1 → XP_038364712.1  glutathione synthetase isoform X2

      Conserved Domains (1) summary
      cl00170
      Location:1 → 405
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

      Range
      24048251..24074736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038636347.1 → XP_038492275.1  glutathione synthetase isoform X1

      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    2. XM_038636348.1 → XP_038492276.1  glutathione synthetase isoform X1

      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    3. XM_038636349.1 → XP_038492277.1  glutathione synthetase isoform X1

      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    4. XM_038636350.1 → XP_038492278.1  glutathione synthetase isoform X2

      Conserved Domains (1) summary
      cl00170
      Location:1 → 405
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

      Range
      24487171..24513688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038572094.1 → XP_038428022.1  glutathione synthetase isoform X1

      UniProtKB/TrEMBL
      A0A8C0QD92, A0A8I3NS50, A0A8I3RZR9
      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    2. XM_038572095.1 → XP_038428023.1  glutathione synthetase isoform X1

      UniProtKB/TrEMBL
      A0A8C0QD92, A0A8I3NS50, A0A8I3RZR9
      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    3. XM_038572096.1 → XP_038428024.1  glutathione synthetase isoform X1

      UniProtKB/TrEMBL
      A0A8C0QD92, A0A8I3NS50, A0A8I3RZR9
      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    4. XM_038572097.1 → XP_038428025.1  glutathione synthetase isoform X2

      UniProtKB/TrEMBL
      A0A8I3RZR9
      Conserved Domains (1) summary
      cl00170
      Location:1 → 405
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23619971..23646466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_846522.6 → XP_851615.1  glutathione synthetase isoform X1

      See identical proteins and their annotated locations for XP_851615.1

      UniProtKB/TrEMBL
      A0A8C0QD92, A0A8I3NS50, A0A8I3RZR9
      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    2. XM_005634964.3 → XP_005635021.1  glutathione synthetase isoform X1

      See identical proteins and their annotated locations for XP_005635021.1

      UniProtKB/TrEMBL
      A0A8C0QD92, A0A8I3NS50, A0A8I3RZR9
      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    3. XM_014106887.3 → XP_013962362.1  glutathione synthetase isoform X1

      UniProtKB/TrEMBL
      A0A8C0QD92, A0A8I3NS50, A0A8I3RZR9
      Conserved Domains (1) summary
      cd00228
      Location:19 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    4. XM_014106888.3 → XP_013962363.1  glutathione synthetase isoform X2

      UniProtKB/TrEMBL
      A0A8I3RZR9
      Conserved Domains (1) summary
      cl00170
      Location:1 → 405
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
    Nucleotide Protein
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