PLEK pleckstrin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PLEKprovided by VGNC
Official Full Name: pleckstrinprovided by VGNC
Primary source: VGNC:VGNC:44666
See related: Ensembl:ENSCAFG00845023363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	10	NC_051814.1 (68415503..68440783)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	10	NC_006592.4 (67285901..67311154)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	10	NC_049231.1 (68691992..68717126)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	10	NC_049270.1 (68098493..68123539)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	10	NC_049751.1 (68396757..68422024)

Chromosome 10 - NC_051814.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pleckstrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003363.3 → NP_001003363.1 pleckstrin

See identical proteins and their annotated locations for NP_001003363.1

Status: VALIDATED

Source sequence(s)

JAAUVH010000358

UniProtKB/Swiss-Prot

Q6Q308

UniProtKB/TrEMBL

A0A8C0PDB5, A0A8C0QSS0, A0A8I3PEC2

Related

ENSCAFP00845032366.1, ENSCAFT00845041284.1

Conserved Domains (3) summary

cd04445
Location:125 → 223

DEP_PLEK1; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, ...

cd13301
Location:3 → 110

PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1

cd13302
Location:239 → 347

PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2