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    CNTFR ciliary neurotrophic factor receptor [ Canis lupus familiaris (dog) ]

    Gene ID: 442941, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CNTFRprovided by VGNC
    Official Full Name
    ciliary neurotrophic factor receptorprovided by VGNC
    Primary source
    VGNC:VGNC:39430
    See related
    Ensembl:ENSCAFG00845024273
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    CNTFRALPHA
    Orthologs
    human mouse all
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    Genomic context

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    See CNTFR in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (52168591..52207166, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (49856718..49885981, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (51464730..51493994, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (50831810..50861067, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (50699974..50729298, complement)

    Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene dynein axonemal intermediate chain 1 Neighboring gene family with sequence similarity 219 member A Neighboring gene energy homeostasis associated Neighboring gene uncharacterized LOC102153363 Neighboring gene ribonuclease P/MRP subunit p25 like Neighboring gene dynactin subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha). Beltran WA, et al. Invest Ophthalmol Vis Sci, 2003 Aug. PMID 12882818
    2. Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells. Buk DM, et al. J Cell Sci, 2004 Apr 15. PMID 15054106

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. each subunit of the CNTF receptor complex has a distinct distribution in polarised cells which may reflect the different roles the respective cytokines play in vivo
      Title: Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ciliary neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CNTFR-CLCF1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of ciliary neurotrophic factor receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ciliary neurotrophic factor receptor subunit alpha
    Names
    CNTF receptor subunit alpha
    CNTFR-alpha
    ciliary neurotrophic factor receptor alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003353.1 → NP_001003353.1  ciliary neurotrophic factor receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_001003353.1

      Status: PROVISIONAL

      Source sequence(s)
      AF529215
      UniProtKB/Swiss-Prot
      Q71DR4
      UniProtKB/TrEMBL
      A0A8C0KTT4, A0A8C0RDC0
      Related
      ENSCAFP00845033692.1, ENSCAFT00845042976.1
      Conserved Domains (3) summary
      smart00408
      Location:39 → 96
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:204 → 300
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:39 → 47
      Ig; Ig strand B [structural motif]

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051815.1 Reference ROS_Cfam_1.0

      Range
      52168591..52207166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038680911.1 → XP_038536839.1  ciliary neurotrophic factor receptor subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      Q71DR4
      UniProtKB/TrEMBL
      A0A8C0KTT4, A0A8C0RDC0
      Conserved Domains (3) summary
      smart00408
      Location:39 → 96
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:204 → 300
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:39 → 47
      Ig; Ig strand B [structural motif]

    2. XM_038680909.1 → XP_038536837.1  ciliary neurotrophic factor receptor subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      Q71DR4
      UniProtKB/TrEMBL
      A0A8C0KTT4, A0A8C0RDC0
      Conserved Domains (3) summary
      smart00408
      Location:39 → 96
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:204 → 300
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:39 → 47
      Ig; Ig strand B [structural motif]

    3. XM_038680908.1 → XP_038536836.1  ciliary neurotrophic factor receptor subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      Q71DR4
      UniProtKB/TrEMBL
      A0A8C0KTT4, A0A8C0RDC0
      Related
      ENSCAFP00845033622.1, ENSCAFT00845042894.1
      Conserved Domains (3) summary
      smart00408
      Location:39 → 96
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:204 → 300
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:39 → 47
      Ig; Ig strand B [structural motif]

    4. XM_038680910.1 → XP_038536838.1  ciliary neurotrophic factor receptor subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      Q71DR4
      UniProtKB/TrEMBL
      A0A8C0KTT4, A0A8C0RDC0
      Conserved Domains (3) summary
      smart00408
      Location:39 → 96
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:204 → 300
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:39 → 47
      Ig; Ig strand B [structural motif]

    5. XM_038680907.1 → XP_038536835.1  ciliary neurotrophic factor receptor subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      Q71DR4
      UniProtKB/TrEMBL
      A0A8C0KTT4, A0A8C0RDC0
      Related
      ENSCAFP00845033758.1, ENSCAFT00845043058.1
      Conserved Domains (3) summary
      smart00408
      Location:39 → 96
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:204 → 300
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:39 → 47
      Ig; Ig strand B [structural motif]

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049271.1 Alternate UMICH_Zoey_3.1

      Range
      50831810..50861067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

      Range
      50699974..50729298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

      Range
      51464730..51493994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      49856718..49885981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q71DR4.1 GenPept UniProtKB/Swiss-Prot:Q71DR4

    Gene LinkOut

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