BIRC5 baculoviral IAP repeat containing 5 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: BIRC5provided by VGNC
Official Full Name: baculoviral IAP repeat containing 5provided by VGNC
Primary source: VGNC:VGNC:38461
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (3608303..3613418, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (3613921..3619074, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (3836949..3842103, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (3631386..3636494, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (3755584..3761556, complement)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results indicate that survivin is commonly expressed in canine lymphomas and that survivin does not exhibit anti-apoptotic activity in canine lymphomas.
Title: Survivin expression in correlation with apoptotic activity in canine lymphomas.
These findings strongly suggest that survivin-directed therapies might be effective in treatment of canine lymphoma and osteoporosis and support evaluation of EZN-3042 in dogs with cancer.
Title: Survivin inhibition via EZN-3042 in canine lymphoma and osteosarcoma.
These findings suggest that survivin could play an important role in the maintenance of the hair follicle cycle as well as in tumour initiation and maintenance of cancer stem cells.
Title: On the role of survivin as a stem cell biomarker of canine hair follicle and related tumours.
The level of survivin expression increased with increasing malignancy, designating survivin as a new diagnostic marker in the assessment of malignancy of sebaceous tumours.
Title: Nuclear survivin expression as a potentially useful tool for the diagnosis of canine cutaneous sebaceous lesions.
This study demonstrated survivin expression in normal canine epidermis; nuclear survivin expression in pre-neoplastic and neoplastic lesions demonstrated a possible association of survivin with development of squamous cell carcinomas in humans and dogs.
Title: Survivin expression in canine epidermis and in canine and human cutaneous squamous cell carcinomas.
Nuclear survivin was detected in transitional cell carcinoma and cystitic tissues but not in normal urinary bladder tissues.
Title: Comparison of distributions of survivin among tissues from urinary bladders of dogs with cystitis, transitional cell carcinoma, or histologically normal urinary bladders.
Survivin overexpression is associated with tumor malignancy in dog.
Title: Expression of survivin mRNA in dog tumors.
Survivin expression is a negative prognostic factor that can predict early treatment failure of dogs that present with stage IIIa or IVa, B-cell LSA when treated with a CHOP-based protocol.
Title: Comparative analysis of survivin expression in untreated and relapsed canine lymphoma.
Malignant proliferation in canine hemangiosarcomas is associated with bcl-2 and survivin expression.
Title: Expression of the anti-apoptotic factors Bcl-2 and survivin in canine vascular tumours.

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General gene information

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General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 5

Names: apoptosis inhibitor survivin; survivin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.