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    ARHGEF7 Rho guanine nucleotide exchange factor 7 [ Gallus gallus (chicken) ]

    Gene ID: 418761, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ARHGEF7provided by CGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 7provided by CGNC
    Primary source
    CGNC:12644
    See related
    Ensembl:ENSGALG00010013080
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF7 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (139315529..139423379)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (139314294..139422076)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109165 Neighboring gene ankyrin repeat domain 10 Neighboring gene uncharacterized LOC121107344 Neighboring gene uncharacterized LOC124417360 Neighboring gene SRY-box 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the endogenous GIT1-betaPIX complex, and identification of its association to membranes. Botrugno OA, et al. Eur J Cell Biol, 2006 Jan. PMID 16373173
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 7
    Names
    Rho guanine nucleotide exchange factor (GEF) 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      139315529..139423379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003640531.5 → XP_003640579.1  rho guanine nucleotide exchange factor 7 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2TZR1, A0A8V0YKD6
      Related
      ENSGALP00010018307.1, ENSGALT00010031379.1
      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:773 → 859
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    2. XM_004938542.5 → XP_004938599.1  rho guanine nucleotide exchange factor 7 isoform X3

      UniProtKB/TrEMBL
      A0A3Q3API9, A0A8V0YKD6
      Related
      ENSGALP00010018310.1, ENSGALT00010031382.1
      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:714 → 800
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    3. XM_025146726.3 → XP_025002494.1  rho guanine nucleotide exchange factor 7 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YKD6
      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:773 → 824
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    4. XM_046903508.1 → XP_046759464.1  rho guanine nucleotide exchange factor 7 isoform X7

    5. XM_046903515.1 → XP_046759471.1  rho guanine nucleotide exchange factor 7 isoform X7

    6. XM_040651008.2 → XP_040506942.1  rho guanine nucleotide exchange factor 7 isoform X7

      UniProtKB/TrEMBL
      A0A8V0YKE6
      Conserved Domains (4) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    7. XM_040651010.2 → XP_040506944.1  rho guanine nucleotide exchange factor 7 isoform X8

      UniProtKB/TrEMBL
      A0A8V0YKE6
      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl27170
      Location:484 → 632
      DUF460; Protein of unknown function (DUF460)

    8. XM_046903533.1 → XP_046759489.1  rho guanine nucleotide exchange factor 7 isoform X9

    9. XM_046903522.1 → XP_046759478.1  rho guanine nucleotide exchange factor 7 isoform X7

    10. XM_040650999.2 → XP_040506933.1  rho guanine nucleotide exchange factor 7 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YIC9, A0A8V0YQ66
      Related
      ENSGALP00010018297.1, ENSGALT00010031365.1
      Conserved Domains (4) summary
      cd12061
      Location:106 → 159
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:190 → 367
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:398 → 496
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:552 → 650
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    11. XM_046903503.1 → XP_046759459.1  rho guanine nucleotide exchange factor 7 isoform X7

    12. XM_004938545.5 → XP_004938602.1  rho guanine nucleotide exchange factor 7 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YQ66
      Conserved Domains (7) summary
      cd12061
      Location:85 → 138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169 → 346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377 → 475
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:531 → 629
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:691 → 777
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:35 → 81
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:1 → 33
      CH_SF; calponin homology (CH) domain superfamily

    13. XM_040651005.2 → XP_040506939.1  rho guanine nucleotide exchange factor 7 isoform X6

      UniProtKB/TrEMBL
      A0A8V0YQ66
      Related
      ENSGALP00010018291.1, ENSGALT00010031359.1
      Conserved Domains (5) summary
      cd12061
      Location:85 → 138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169 → 346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377 → 475
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:531 → 629
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl27170
      Location:559 → 707
      DUF460; Protein of unknown function (DUF460)

    14. XM_046903539.1 → XP_046759495.1  rho guanine nucleotide exchange factor 7 isoform X10

    RNA

    1. XR_001464001.4 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      139314294..139422076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040658963.2 → XP_040514897.1  rho guanine nucleotide exchange factor 7 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2TZR1, A0A8V0YKD6
      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:773 → 859
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    2. XM_040658965.2 → XP_040514899.1  rho guanine nucleotide exchange factor 7 isoform X3

      UniProtKB/TrEMBL
      A0A3Q3API9, A0A8V0YKD6
      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:714 → 800
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    3. XM_040658964.2 → XP_040514898.1  rho guanine nucleotide exchange factor 7 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YKD6
      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:773 → 824
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    4. XM_046909782.1 → XP_046765738.1  rho guanine nucleotide exchange factor 7 isoform X7

    5. XM_046909783.1 → XP_046765739.1  rho guanine nucleotide exchange factor 7 isoform X7

    6. XM_040658969.2 → XP_040514903.1  rho guanine nucleotide exchange factor 7 isoform X7

      UniProtKB/TrEMBL
      A0A8V0YKE6
      Conserved Domains (4) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    7. XM_040658970.2 → XP_040514904.1  rho guanine nucleotide exchange factor 7 isoform X8

      UniProtKB/TrEMBL
      A0A8V0YKE6
      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl27170
      Location:484 → 632
      DUF460; Protein of unknown function (DUF460)

    8. XM_046909784.1 → XP_046765740.1  rho guanine nucleotide exchange factor 7 isoform X7

    9. XM_040658967.2 → XP_040514901.1  rho guanine nucleotide exchange factor 7 isoform X11

      UniProtKB/TrEMBL
      A0A8V0YQ66
      Conserved Domains (4) summary
      cd12061
      Location:84 → 137
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:168 → 345
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:376 → 474
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:530 → 628
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    10. XM_046909781.1 → XP_046765737.1  rho guanine nucleotide exchange factor 7 isoform X7

    11. XM_040658966.2 → XP_040514900.1  rho guanine nucleotide exchange factor 7 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YQ66
      Conserved Domains (7) summary
      cd12061
      Location:85 → 138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169 → 346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377 → 475
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:531 → 629
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:691 → 777
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:35 → 81
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:1 → 33
      CH_SF; calponin homology (CH) domain superfamily

    12. XM_040658968.2 → XP_040514902.1  rho guanine nucleotide exchange factor 7 isoform X6

      UniProtKB/TrEMBL
      A0A8V0YQ66
      Conserved Domains (5) summary
      cd12061
      Location:85 → 138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169 → 346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377 → 475
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:531 → 629
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl27170
      Location:559 → 707
      DUF460; Protein of unknown function (DUF460)

    13. XM_046909785.1 → XP_046765741.1  rho guanine nucleotide exchange factor 7 isoform X10

    RNA

    1. XR_005844265.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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