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    FGF7 fibroblast growth factor 7 [ Gallus gallus (chicken) ]

    Gene ID: 415439, updated on 17-Aug-2024

    Summary

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    Symbol
    FGF7provided by CGNC
    Full Name
    fibroblast growth factor 7provided by CGNC
    Primary source
    CGNC:66242
    See related
    Ensembl:ENSGALG00010016094
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See FGF7 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (10561115..10592011)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (10434364..10463349)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227 member B Neighboring gene uncharacterized LOC107054189 Neighboring gene DTW domain containing 1 Neighboring gene spermatogenesis associated 5 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FGF signaling segregates biliary cell-lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro. Yanai M, et al. Dev Dyn, 2008 May. PMID 18393311
    2. Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. Shin M, et al. Gene Expr Patterns, 2005 Apr. PMID 15749079
    3. Cloning and expression analysis of Fgf5, 6 and 7 during early chick development. Kumar M, et al. Gene Expr Patterns, 2012 Aug-Sep. PMID 22634565, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fgf6 and Fgf7, although belonging to different subfamilies with diverged sequences, are expressed in similar patterns within the mesoderm
      Title: Cloning and expression analysis of Fgf5, 6 and 7 during early chick development.
    2. These data strongly suggest that bFGF and FGF7 promote biliary epithelial cell differentiation cooperatively with BMP4 and extracellular matrix in vivo.
      Title: FGF signaling segregates biliary cell-lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro.
    3. FGF receptors are expressed only in epithelia of the embryonic digestive tract.
      Title: Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables type 2 fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor 7
    Names
    fibroblast growth factor 7 (keratinocyte growth factor)
    keratinocyte growth factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012525.1 → NP_001012543.1  fibroblast growth factor 7

      See identical proteins and their annotated locations for NP_001012543.1

      Status: PROVISIONAL

      Source sequence(s)
      AB193566
      UniProtKB/TrEMBL
      Q5KRA4, R4GL03
      Conserved Domains (1) summary
      pfam00167
      Location:65 → 189
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      10561115..10592011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015291987.4 → XP_015147473.1  fibroblast growth factor 7 isoform X2

      UniProtKB/TrEMBL
      Q5KRA4, R4GL03
      Related
      ENSGALP00010022382.1, ENSGALT00010038699.1
      Conserved Domains (1) summary
      pfam00167
      Location:65 → 189
      FGF; Fibroblast growth factor

    2. XM_015291985.4 → XP_015147471.1  fibroblast growth factor 7 isoform X1

      Conserved Domains (1) summary
      pfam00167
      Location:71 → 195
      FGF; Fibroblast growth factor

    3. XM_015291989.4 → XP_015147475.1  fibroblast growth factor 7 isoform X3

      Conserved Domains (1) summary
      pfam00167
      Location:48 → 172
      FGF; Fibroblast growth factor

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      10434364..10463349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046924831.1 → XP_046780787.1  fibroblast growth factor 7 isoform X2

      UniProtKB/TrEMBL
      Q5KRA4, R4GL03

    2. XM_046924830.1 → XP_046780786.1  fibroblast growth factor 7 isoform X1

    3. XM_046924832.1 → XP_046780788.1  fibroblast growth factor 7 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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