MAGEA6 MAGE family member A6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAGEA6provided by HGNC
Official Full Name: MAGE family member A6provided by HGNC
Primary source: HGNC:HGNC:6804
See related: Ensembl:ENSG00000197172 MIM:300176; AllianceGenome:HGNC:6804
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT1.6; MAGE6; MAGE3B; MAGE-3b
Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression: Restricted expression toward testis (RPKM 6.4) See more
Orthologs: all
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Genomic context

Location:: Xq28

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (152766136..152769689, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (151032689..151036258, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (151934652..151938198, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of MAGE-A6 enhanced the irradiation sensitivity of non-small cell lung cancer cells by activating the AMPK pathway.
Title: Knockdown of MAGE-A6 enhanced the irradiation sensitivity of non-small cell lung cancer cells by activating the AMPK pathway.
Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.
Title: Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.
Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression.
Title: Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression.
Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling.
Title: Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling.
data indicate that the activation of CT-GABRA3 is correlated with that of MAGEA6. Therefore, MAGEA6 is linked with CT-GABRA3 through a bidirectional promoter.
Title: Epigenetic Coactivation of MAGEA6 and CT-GABRA3 Defines Orientation of a Segmental Duplication in the Human X Chromosome.
High MAGEA6 expression is associated with recurrence in Gastric Cancer.
Title: Tissue Expression of Melanoma-associated Antigen A6 and Clinical Characteristics of Gastric Cancer.
Data indicate that miR-1273g represses melanoma antigen family A 3/melanoma antigen family A 6 (MAGEA3/6 )expression in colorectal cancer (CRC) cells and tissues, which may suggest a cancer-specific therapeutic.
Title: miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling.
MAGEA6 knockdown by targeted-shRNA induced AMPK stabilization and activation, which led to mTOR complex 1 (mTORC1) in-activation and RCC cell death/apoptosis.
Title: Knockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells.
MAGEA6 promotes glioma cell survival possibly via targeting AMPKalpha1.
Title: MAGEA6 promotes human glioma cell survival via targeting AMPKα1.
MageA6 and MageA11 form a protein complex resulting in the stabilization of MageA11 and consequently the enhancement of androgen receptor activity.
Title: Functional interaction between co-expressed MAGE-A proteins.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of melanoma antigen family A, 6 (MAGEA6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:581719 (e-PCR)
- UniSTS:157867

SHGC-35597 (e-PCR)
- UniSTS:70605

SHGC-35594 (e-PCR)
- UniSTS:70606

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: melanoma-associated antigen 6

Names: MAGE-6 antigen; MAGE3B antigen; cancer/testis antigen 1.6; cancer/testis antigen family 1, member 6; melanoma antigen family A, 6; melanoma antigen family A6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005363.5 → NP_005354.1 melanoma-associated antigen 6

See identical proteins and their annotated locations for NP_005354.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC244102

Consensus CDS

CCDS76050.1

UniProtKB/Swiss-Prot

A8IF93, P43360, Q6NW44

UniProtKB/TrEMBL

Q6FGT7, Q6FHI5

Related

ENSP00000329199.5, ENST00000329342.10

Conserved Domains (2) summary

pfam01454
Location:116 → 280

MAGE; MAGE family

pfam12440
Location:5 → 94

MAGE_N; Melanoma associated antigen family N terminal
NM_175868.4 → NP_787064.1 melanoma-associated antigen 6

See identical proteins and their annotated locations for NP_787064.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC244102

Consensus CDS

CCDS76050.1

UniProtKB/Swiss-Prot

A8IF93, P43360, Q6NW44

UniProtKB/TrEMBL

Q6FGT7, Q6FHI5

Related

ENSP00000480637.1, ENST00000616035.4

Conserved Domains (2) summary

pfam01454
Location:116 → 280

MAGE; MAGE family

pfam12440
Location:5 → 94

MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

152766136..152769689 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

NW_025791818.1 Reference GRCh38.p14 PATCHES

Range

313913..317471

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333342.1 → XP_054189317.1 melanoma-associated antigen 6 isoform X1

UniProtKB/Swiss-Prot

A8IF93, P43360, Q6NW44
XM_054333341.1 → XP_054189316.1 melanoma-associated antigen 6 isoform X1

UniProtKB/Swiss-Prot

A8IF93, P43360, Q6NW44
XM_054333343.1 → XP_054189318.1 melanoma-associated antigen 6 isoform X1

UniProtKB/Swiss-Prot

A8IF93, P43360, Q6NW44

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

151032689..151036258 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054327060.1 → XP_054183035.1 melanoma-associated antigen 6 isoform X1

UniProtKB/Swiss-Prot

P43357, Q6FHI6
XM_054327059.1 → XP_054183034.1 melanoma-associated antigen 6 isoform X1

UniProtKB/Swiss-Prot

P43357, Q6FHI6
XM_054327061.1 → XP_054183036.1 melanoma-associated antigen 6 isoform X1

UniProtKB/Swiss-Prot

P43357, Q6FHI6