F11 coagulation factor XI [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: F11provided by VGNC
Official Full Name: coagulation factor XIprovided by VGNC
Primary source: VGNC:VGNC:28678
See related: BGD:BT10101; Ensembl:ENSBTAG00000003572
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: FXI
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 27

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	27	NC_037354.1 (16294235..16313378)

Chromosome 27 - NC_037354.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.
Title: Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.
Sequence analysis of the bovine coagulation factor XI (F11) gene revealed an unusually high number of non-synonymous mutations. However, none of the mutations in the F11 gene were concordant with Bovine neonatal pancytopenia status.
Title: A genetic predisposition for bovine neonatal pancytopenia is not due to mutations in coagulation factor XI.
The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene
Title: Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle.
DNA was extracted and amplified from the bovine mummified fetuses, and the samples were successfully tested for Factor XI gene deficiency in the mummies.
Title: DNA extraction from bovine mummified fetuses and detection of factor XI gene deficiency in the mummies.
Insertion of 15 nucleotides in the F11 gene is the causative mutation for factor XI deficiency in Japanese black cattle.
Title: An insertion mutation of the bovine Fii gene is responsible for factor XI deficiency in Japanese black cattle.

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General gene information

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Markers

F11-2 (e-PCR), detects polymorphism
- UniSTS:251592

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: coagulation factor XI

Names: PTA; blood coagulation factor XI; plasma thromboplastin antecedent

NP_001008665.1

EC 3.4.21.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008665.1 → NP_001008665.1 coagulation factor XI precursor

See identical proteins and their annotated locations for NP_001008665.1

Status: PROVISIONAL

Source sequence(s)

AB196307

UniProtKB/Swiss-Prot

Q5NTB3

UniProtKB/TrEMBL

F1MUT4

Related

ENSBTAP00000004648.3, ENSBTAT00000004648.5

Conserved Domains (3) summary

smart00223
Location:291 → 374

APPLE; APPLE domain

smart00020
Location:387 → 618

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:388 → 618

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...