galcb galactosylceramidase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: galcbprovided by ZNC
Official Full Name: galactosylceramidase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2115
See related: Ensembl:ENSDARG00000016474 AllianceGenome:ZFIN:ZDB-GENE-040426-2115
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: galc; zgc:56444; wu:fi04e07
Summary: Enables galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Predicted to act upstream of or within lipid catabolic process and sphingolipid metabolic process. Located in lysosome. Is expressed in melanoblast and nervous system. Used to study melanoma. Human ortholog(s) of this gene implicated in Krabbe disease. Orthologous to human GALC (galactosylceramidase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (18889126..18898082, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (18869801..18878246, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables galactosylceramidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylceramidase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylceramidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in galactosylceramide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within galactosylceramide catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: galactocerebrosidase

NP_998276.2

EC 3.2.1.46

XP_068070479.1

EC 3.2.1.46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.