SEC61A1 SEC61 translocon subunit alpha 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SEC61A1provided by VGNC
Official Full Name: SEC61 translocon subunit alpha 1provided by VGNC
Primary source: VGNC:VGNC:49614
See related: Ensembl:ENSCAFG00845018244
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	20	NC_051824.1 (2091105..2109038)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	20	NC_006602.4 (2106985..2124750)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	20	NC_049241.1 (2099082..2117009)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	20	NC_049280.1 (1812164..1829894)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	20	NC_049761.1 (2138938..2156767)

Chromosome 20 - NC_051824.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the Inhibited State of the Sec Translocon.
Title: Structure of the Inhibited State of the Sec Translocon.
CaM binding to the cytosolic N-terminus of Sec61alpha is involved in limiting Ca(2+)-leakage from the ER in C. familiaris but not S. cerevisiae.
Title: Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates.
Calmodulin binds to a conserved motif of the Sec61 alpha subunit in a calcium-dependent and sequence-specific manner.
Title: Interaction of calmodulin with Sec61α limits Ca2+ leakage from the endoplasmic reticulum.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signal sequence binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of Sec61 translocon complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein transport protein Sec61 subunit alpha isoform 1

Names: SEC61 translocon alpha 1 subunit; protein transport protein Sec61 subunit alpha; sec61 alpha-1; sec61 homologue

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.