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    NR4A1 nuclear receptor subfamily 4 group A member 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 403897, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NR4A1provided by VGNC
    Official Full Name
    nuclear receptor subfamily 4 group A member 1provided by VGNC
    Primary source
    VGNC:VGNC:43954
    See related
    Ensembl:ENSCAFG00845026982
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    NGFI-B
    Orthologs
    human mouse all
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    Genomic context

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    See NR4A1 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (2944790..2966939, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (43300499..43308433)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (43698715..43706655)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (2961332..2969256, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (2947820..2955733, complement)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 41 Neighboring gene autophagy related 101 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene activin A receptor type 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of nerve growth factor-induced gene-B (NGFI-B) as an early event in the cyclic adenosine monophosphate response of dog thyrocytes in primary culture. Pichon B, et al. Endocrinology, 1996 Nov. PMID 8895335
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear glucocorticoid receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to corticotropin-releasing hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor subfamily 4 group A member 1
    Names
    orphan nuclear receptor HMR
    orphan nuclear receptor NGFI-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003227.1 → NP_001003227.1  nuclear receptor subfamily 4 group A member 1

      See identical proteins and their annotated locations for NP_001003227.1

      Status: PROVISIONAL

      Source sequence(s)
      X97226
      UniProtKB/Swiss-Prot
      P51666
      UniProtKB/TrEMBL
      A0A8C0JK87, A0A8C0P5G0
      Related
      ENSCAFP00845037687.1, ENSCAFT00845048033.1
      Conserved Domains (2) summary
      cd07348
      Location:361 → 598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265 → 339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      2944790..2966939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038437740.1 → XP_038293668.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      UniProtKB/Swiss-Prot
      P51666
      UniProtKB/TrEMBL
      A0A8C0JK87, A0A8C0P5G0
      Conserved Domains (2) summary
      cd07348
      Location:361 → 598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265 → 339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    2. XM_038437744.1 → XP_038293672.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      UniProtKB/Swiss-Prot
      P51666
      UniProtKB/TrEMBL
      A0A8C0JK87, A0A8C0P5G0
      Conserved Domains (2) summary
      cd07348
      Location:361 → 598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265 → 339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    3. XM_038437739.1 → XP_038293667.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      UniProtKB/Swiss-Prot
      P51666
      UniProtKB/TrEMBL
      A0A8C0JK87, A0A8C0P5G0
      Conserved Domains (2) summary
      cd07348
      Location:361 → 598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265 → 339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    4. XM_038437743.1 → XP_038293671.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      UniProtKB/Swiss-Prot
      P51666
      UniProtKB/TrEMBL
      A0A8C0JK87, A0A8C0P5G0
      Conserved Domains (2) summary
      cd07348
      Location:361 → 598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265 → 339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    5. XM_038437742.1 → XP_038293670.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      UniProtKB/Swiss-Prot
      P51666
      UniProtKB/TrEMBL
      A0A8C0JK87, A0A8C0P5G0
      Related
      ENSCAFP00845037598.1, ENSCAFT00845047929.1
      Conserved Domains (2) summary
      cd07348
      Location:361 → 598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265 → 339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      2961332..2969256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      2947820..2955733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      43698715..43706655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      43300499..43308433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51666.1 GenPept UniProtKB/Swiss-Prot:P51666

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