PDPN podoplanin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PDPNprovided by VGNC
Official Full Name: podoplaninprovided by VGNC
Primary source: VGNC:VGNC:52226
See related: Ensembl:ENSCAFG00845001081
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: GP40
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (84202661..84231307, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (80087666..80116300, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (83039588..83068230, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (80955029..80983745, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (81973249..82001951, complement)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An Antibody-drug conjugate (ADC) developed using the chemical conjugation by affinity peptide (CCAP) method is useful for antibody therapy against dog podoplanin (dPDPN)-expressing canine squamous cell carcinomas (SCCs) and melanomas.
Title: Antibody-Drug Conjugates Using Mouse-Canine Chimeric Anti-Dog Podoplanin Antibody Exerts Antitumor Activity in a Mouse Xenograft Model.
PDPN Is Expressed in Various Types of Canine Tumors and Its Silencing Induces Apoptosis and Cell Cycle Arrest in Canine Malignant Melanoma.
Title: PDPN Is Expressed in Various Types of Canine Tumors and Its Silencing Induces Apoptosis and Cell Cycle Arrest in Canine Malignant Melanoma.
High PDPN expression is associated with Mammary Cancers.
Title: Expression of Podoplanin in Mammary Cancers in Female Dogs.
PMab-38 is expected to be useful for investigating the function of podoplanin in canine tumors.
Title: PMab-38 Recognizes Canine Podoplanin of Squamous Cell Carcinomas.
PMab-38 also detected dPDPN specifically in flow cytometry and Western blot analysis. PMab-38 is expected to be useful for investigating the function of dPDPN, which is expressed in podocytes.
Title: Specific Detection of Dog Podoplanin Expressed in Renal Glomerulus by a Novel Monoclonal Antibody PMab-38 in Immunohistochemistry.
Podoplanin is expressed in lymphatic endothelial cells and cancer-associated fibroblasts of oral melanoma tissues.
Title: Podoplanin Expression in Canine Melanoma.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chemokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in actin-mediated cell contraction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lung development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of extracellular matrix disassembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of platelet aggregation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of lamellipodium morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of myofibroblast contraction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to hyperoxia	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: podoplanin

Names: glycoprotein 38; gp38; mucin-type membrane protein gp40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.