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    STXBP2 syntaxin binding protein 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 403880, updated on 17-Aug-2024

    Summary

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    Official Symbol
    STXBP2provided by VGNC
    Official Full Name
    syntaxin binding protein 2provided by VGNC
    Primary source
    VGNC:VGNC:46960
    See related
    Ensembl:ENSCAFG00845027713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    MUNC-18-2
    Orthologs
    human mouse all
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    Genomic context

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    See STXBP2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (52942478..52950859)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (52217265..52225592)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (52820884..52829229)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (52146293..52154615)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (52589880..52598195)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene XPA binding protein 2 Neighboring gene protein PET100 homolog, mitochondrial Neighboring gene Purkinje cell protein 2 Neighboring gene resistin Neighboring gene mast cell expressed membrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The syntaxin 4 N terminus regulates its basolateral targeting by munc18c-dependent and -independent mechanisms. Torres J, et al. J Biol Chem, 2011 Mar 25. PMID 21278252, Free PMC Article
    2. A sec1-related vesicle-transport protein that is expressed predominantly in epithelial cells. Riento K, et al. Eur J Biochem, 1996 Aug 1. PMID 8774707
    3. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, et al. Mol Biol Cell, 2007 Jul. PMID 17442889, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The syntaxin 4 N terminus regulates its basolateral targeting by munc18c-dependent and -independent mechanisms.
      Title: The syntaxin 4 N terminus regulates its basolateral targeting by munc18c-dependent and -independent mechanisms.
    2. In a yeast two-hybrid screen the EF-hand Ca(2+)-binding protein Cab45 was identified as an interaction partner of Munc18b.
      Title: A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables syntaxin-3 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle docking involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    syntaxin-binding protein 2
    Names
    Sec1 homolog
    protein unc-18 homolog 2
    protein unc-18 homolog B
    unc-18 homolog 2
    unc-18B
    unc18-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003216.1 → NP_001003216.1  syntaxin-binding protein 2

      See identical proteins and their annotated locations for NP_001003216.1

      Status: PROVISIONAL

      Source sequence(s)
      L41609
      UniProtKB/Swiss-Prot
      Q28288
      UniProtKB/TrEMBL
      A0A8C0LG51, A0A8C0T3N4, A0A8I3PYG0
      Related
      ENSCAFP00845038487.1, ENSCAFT00845049049.1
      Conserved Domains (1) summary
      pfam00995
      Location:29 → 573
      Sec1; Sec1 family

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      52942478..52950859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038426373.1 → XP_038282301.1  syntaxin-binding protein 2 isoform X2

      Conserved Domains (1) summary
      pfam00995
      Location:29 → 445
      Sec1; Sec1 family

    2. XM_038426371.1 → XP_038282299.1  syntaxin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3N4, A0A8I3PYG0
      Conserved Domains (1) summary
      pfam00995
      Location:1 → 541
      Sec1; Sec1 family

    3. XM_038426372.1 → XP_038282300.1  syntaxin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0T3N4, A0A8I3PYG0
      Conserved Domains (1) summary
      pfam00995
      Location:1 → 541
      Sec1; Sec1 family

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      52146293..52154615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      52589880..52598195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      52820884..52829229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      52217265..52225592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28288.1 GenPept UniProtKB/Swiss-Prot:Q28288

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials