GLB1 galactosidase beta 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: GLB1provided by VGNC
Official Full Name: galactosidase beta 1provided by VGNC
Primary source: VGNC:VGNC:41249
See related: Ensembl:ENSCAFG00845023378
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	23	NC_051827.1 (3992209..4074051)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	23	NC_006605.4 (3776393..3858177)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	23	NC_049244.1 (3927851..4009519)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	23	NC_049283.1 (3826915..3908721)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	23	NC_049764.1 (3954230..4036008)

Chromosome 23 - NC_051827.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first study that simultaneously examine the effect of GLB1(+/+), GLB1(+/-) and GLB1(-/-) genotypes on the expression of lysosomal multienzyme complex components.
Title: Impact of beta-galactosidase mutations on the expression of the canine lysosomal multienzyme complex.
canine model is an appropriate animal model for the human late infantile form and represents a versatile system to test gene therapeutic approaches for human and canine G(M1)-gangliosidosis
Title: Insights into post-translational processing of beta-galactosidase in an animal model resembling late infantile human G-gangliosidosis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables beta-galactosidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in vacuole	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-galactosidase

Names: acid beta-galactosidase; lactase; lysosomal beta-galactosidase

NP_001032730.1

EC 3.2.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.