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    CASP4 caspase 4, apoptosis-related cysteine peptidase [ Canis lupus familiaris (dog) ]

    Gene ID: 403724, updated on 22-Jan-2024

    Summary

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    Gene symbol
    CASP4
    Gene description
    caspase 4, apoptosis-related cysteine peptidase
    See related
    Ensembl:ENSCAFG00845000375
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    CASP1; IL1BC
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See CASP4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (27170519..27184696)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (27064601..27078777)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (27257464..27271644)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (27212077..27226245)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (27098364..27112532)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 4 with coiled-coils Neighboring gene glutamate ionotropic receptor AMPA type subunit 4 Neighboring gene 60 kDa heat shock protein, mitochondrial-like Neighboring gene uncharacterized LOC119871825 Neighboring gene uncharacterized LOC106558805 Neighboring gene caspase 12 Neighboring gene 14-3-3 protein theta-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides. Taylor S, et al. DNA Seq, 2000. PMID 10826695
    2. Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire. Eckhart L, et al. Mol Biol Evol, 2008 May. PMID 18281271
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables caspase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase-1
    Names
    CASP-1
    ICE
    IL-1 beta-converting enzyme
    IL-1BC
    caspase-1/caspase-4 hybrid
    interleukin-1 beta convertase
    interleukin-1 beta-converting enzyme
    p45
    NP_001003125.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003125.1 → NP_001003125.1  caspase-1

      See identical proteins and their annotated locations for NP_001003125.1

      Status: PROVISIONAL

      Source sequence(s)
      AF135967
      UniProtKB/Swiss-Prot
      Q9MZV7
      UniProtKB/TrEMBL
      A0A8C0MQW5
      Related
      ENSCAFP00845000456.1, ENSCAFT00845000645.1
      Conserved Domains (2) summary
      smart00115
      Location:153 → 402
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:5 → 87
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      27170519..27184696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      27212077..27226245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      27098364..27112532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      27257464..27271644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      27064601..27078777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MZV7.1 GenPept UniProtKB/Swiss-Prot:Q9MZV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.