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    SGK1 serum/glucocorticoid regulated kinase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 403647, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SGK1provided by VGNC
    Official Full Name
    serum/glucocorticoid regulated kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:46097
    See related
    Ensembl:ENSCAFG00845004995
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    SGK
    Orthologs
    human mouse all
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    Genomic context

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    See SGK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (27245018..27354617, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (27967769..28077630, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (27318579..27428323, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (27128500..27238272, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (27008812..27118227, complement)

    Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 12 Neighboring gene TATA-box binding protein like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC119870650 Neighboring gene uncharacterized LOC106558449

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The alpha-subunit of the epithelial sodium channel is an aldosterone-induced transcript in mammalian collecting ducts, and this transcriptional response is mediated via distinct cis-elements in the 5'-flanking region of the gene. Mick VE, et al. Mol Endocrinol, 2001 Apr. PMID 11266509
    2. A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. Andersen MN, et al. J Biol Chem, 2013 Dec 27. PMID 24214981, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI3K-SGK1 pathway stabilizes Kv7.1 surface expression by inhibiting Nedd4-2-dependent endocytosis and thereby demonstrates that Nedd4-2 is a key regulator of Kv7.1 localization and turnover in epithelial cells.
      Title: A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Sgk1
    Names
    serum/glucocorticoid regulatory kinase
    XP_003432572.1
    XP_038321371.1
    XP_038321372.1
    XP_038321373.1
    XP_038321374.1
    XP_038348839.1
    XP_038381988.1
    XP_038381989.1
    XP_038381990.1
    XP_038381991.1
    XP_038446282.1
    XP_038446283.1
    XP_038446284.1
    XP_038446285.1
    XP_038510107.1
    XP_038510108.1
    XP_038510109.1
    XP_038510110.1
    XP_849801.1
    XP_859942.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051805.1 Reference ROS_Cfam_1.0

      Range
      27245018..27354617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038654179.1 → XP_038510107.1  serine/threonine-protein kinase Sgk1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MBX1, A0A8C0MDE8, A0A8I3RSF1
      Related
      ENSCAFP00845007074.1, ENSCAFT00845008973.1
      Conserved Domains (1) summary
      cd05575
      Location:197 → 519
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

    2. XM_038654182.1 → XP_038510110.1  serine/threonine-protein kinase Sgk1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q1J9, A0A8C0RUH7, A0A8I3MU12, A0A8I3NAH4
      Related
      ENSCAFP00845007055.1, ENSCAFT00845008949.1
      Conserved Domains (1) summary
      cd05602
      Location:76 → 414
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    3. XM_038654180.1 → XP_038510108.1  serine/threonine-protein kinase Sgk1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PX76, A0A8C0RUH7, A0A8I3MYD8, A0A8I3NAH4
      Related
      ENSCAFP00845007060.1, ENSCAFT00845008956.1
      Conserved Domains (1) summary
      cd05602
      Location:104 → 442
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    4. XM_038654181.1 → XP_038510109.1  serine/threonine-protein kinase Sgk1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LBB6, A0A8C0Q1N0, A0A8C0RUH7, A0A8I3NAH4, A0A8I3RTW6
      Related
      ENSCAFP00845007061.1, ENSCAFT00845008958.1
      Conserved Domains (1) summary
      cd05602
      Location:90 → 428
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049261.1 Alternate UMICH_Zoey_3.1

      Range
      27128500..27238272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038465443.1 → XP_038321371.1  serine/threonine-protein kinase Sgk1 isoform X1

      Conserved Domains (1) summary
      cd05575
      Location:197 → 519
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

    2. XM_038465446.1 → XP_038321374.1  serine/threonine-protein kinase Sgk1 isoform X4

      Conserved Domains (1) summary
      cd05602
      Location:76 → 414
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    3. XM_038465444.1 → XP_038321372.1  serine/threonine-protein kinase Sgk1 isoform X2

      Conserved Domains (1) summary
      cd05602
      Location:104 → 442
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    4. XM_038465445.1 → XP_038321373.1  serine/threonine-protein kinase Sgk1 isoform X3

      Conserved Domains (1) summary
      cd05602
      Location:90 → 428
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

      Range
      27008812..27118227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038590354.1 → XP_038446282.1  serine/threonine-protein kinase Sgk1 isoform X1

      Conserved Domains (1) summary
      cd05575
      Location:197 → 519
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

    2. XM_038590357.1 → XP_038446285.1  serine/threonine-protein kinase Sgk1 isoform X4

      Conserved Domains (1) summary
      cd05602
      Location:76 → 414
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    3. XM_038590355.1 → XP_038446283.1  serine/threonine-protein kinase Sgk1 isoform X2

      Conserved Domains (1) summary
      cd05602
      Location:104 → 442
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    4. XM_038590356.1 → XP_038446284.1  serine/threonine-protein kinase Sgk1 isoform X3

      Conserved Domains (1) summary
      cd05602
      Location:90 → 428
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

      Range
      27318579..27428323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038526060.1 → XP_038381988.1  serine/threonine-protein kinase Sgk1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MBX1, A0A8C0MDE8, A0A8I3RSF1
      Conserved Domains (1) summary
      cd05575
      Location:197 → 519
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

    2. XM_038526063.1 → XP_038381991.1  serine/threonine-protein kinase Sgk1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0Q1J9, A0A8C0RUH7, A0A8I3MU12, A0A8I3NAH4
      Conserved Domains (1) summary
      cd05602
      Location:76 → 414
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    3. XM_038526061.1 → XP_038381989.1  serine/threonine-protein kinase Sgk1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PX76, A0A8C0RUH7, A0A8I3MYD8, A0A8I3NAH4
      Conserved Domains (1) summary
      cd05602
      Location:104 → 442
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    4. XM_038526062.1 → XP_038381990.1  serine/threonine-protein kinase Sgk1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LBB6, A0A8C0Q1N0, A0A8C0RUH7, A0A8I3NAH4, A0A8I3RTW6
      Conserved Domains (1) summary
      cd05602
      Location:90 → 428
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      27967769..28077630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003432524.5 → XP_003432572.1  serine/threonine-protein kinase Sgk1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MBX1, A0A8C0MDE8, A0A8I3RSF1
      Conserved Domains (1) summary
      cd05575
      Location:197 → 519
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

    2. XM_854849.6 → XP_859942.1  serine/threonine-protein kinase Sgk1 isoform X4

      See identical proteins and their annotated locations for XP_859942.1

      UniProtKB/TrEMBL
      A0A8C0Q1J9, A0A8C0RUH7, A0A8I3MU12, A0A8I3NAH4
      Conserved Domains (1) summary
      cd05602
      Location:76 → 414
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    3. XM_038492911.1 → XP_038348839.1  serine/threonine-protein kinase Sgk1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PX76, A0A8C0RUH7, A0A8I3MYD8, A0A8I3NAH4
      Conserved Domains (1) summary
      cd05602
      Location:104 → 442
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    4. XM_844708.6 → XP_849801.1  serine/threonine-protein kinase Sgk1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LBB6, A0A8C0Q1N0, A0A8C0RUH7, A0A8I3NAH4, A0A8I3RTW6
      Conserved Domains (1) summary
      cd05602
      Location:90 → 428
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
    Nucleotide Protein
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