U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ESR1 estrogen receptor 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 403640, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ESR1provided by VGNC
    Official Full Name
    estrogen receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:40476
    See related
    Ensembl:ENSCAFG00845000028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    ERALPHA
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ESR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (42267417..42551842)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (42923315..43207109)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (42491321..42775607)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (42140418..42417150)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (41990600..42280338)

    Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095762 Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC119870753 Neighboring gene uncharacterized LOC102151483 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene MYC target 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Estrogen receptors genotypes and canine mammary neoplasia. Canadas-Sousa A, et al. BMC Vet Res, 2019 Sep 10. PMID 31506083, Free PMC Article
    2. The ESR1 gene is associated with risk for canine mammary tumours. Borge KS, et al. BMC Vet Res, 2013 Apr 10. PMID 23574728, Free PMC Article
    3. Homozygosity of single nucleotide polymorphisms in the 3' region of the canine estrogen receptor 1 gene is greater in Toy Poodles than in Miniature Dachshunds and Chihuahuas. Pathirana IN, et al. Anim Sci J, 2011 Jun. PMID 21615831
    4. Analysis of single nucleotide polymorphisms in the 3' region of the estrogen receptor 1 gene in normal and cryptorchid Miniature Dachshunds and Chihuahuas. Pathirana IN, et al. J Reprod Dev, 2010 Aug. PMID 20453437
    5. ERalpha increases expression and interacts with TERT in cataractous canine lens epithelial cells. Colitz CM, et al. Mol Vis, 2009 Nov 9. PMID 19936027, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p53, ER, and Ki67 Expression in Canine Mammary Carcinomas and Correlation With Pathological Variables and Prognosis.
      Title: p53, ER, and Ki67 Expression in Canine Mammary Carcinomas and Correlation With Pathological Variables and Prognosis.
    2. the association between seven single nucleotide polymorphisms (SNPs) in canine ESR1 gene and clinicopathological features of canine mammary tumors and the clinical outcome of the disease
      Title: Estrogen receptors genotypes and canine mammary neoplasia.
    3. We concluded that sex steroid receptors and apoptotic proteins are differentially expressed in the follicles of adult dogs with polystic ovaries
      Title: Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs.
    4. associated with risk for mammary tumours
      Title: The ESR1 gene is associated with risk for canine mammary tumours.
    5. These results imply that homozygosity for the allele, genotype and haplotype distribution within the block at the 3' end of ESR1 is greater in Toy Poodles than in Miniature Dachshunds and Chihuahuas.
      Title: Homozygosity of single nucleotide polymorphisms in the 3' region of the canine estrogen receptor 1 gene is greater in Toy Poodles than in Miniature Dachshunds and Chihuahuas.
    6. Analysis of SNPs in 3'region of esr1 in cryptorchid dogs.
      Title: Analysis of single nucleotide polymorphisms in the 3' region of the estrogen receptor 1 gene in normal and cryptorchid Miniature Dachshunds and Chihuahuas.
    7. TERT interacted with ERalpha via the estrogen response element (ERE) in cataractous lens epithelial cells (LEC) but not in normal LEC.
      Title: ERalpha increases expression and interacts with TERT in cataractous canine lens epithelial cells.
    8. A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.
      Title: A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    estrogen receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286958.2 → NP_001273887.1  estrogen receptor

      See identical proteins and their annotated locations for NP_001273887.1

      Status: VALIDATED

      Source sequence(s)
      JAAUVH010000354
      UniProtKB/TrEMBL
      A0A8C0KQE4, A0A8C0SV34, A0A8I3MAV6
      Related
      ENSCAFP00845000028.1, ENSCAFT00845000042.1
      Conserved Domains (4) summary
      cd06949
      Location:311 → 548
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:181 → 262
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:40 → 182
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:557 → 596
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051805.1 Reference ROS_Cfam_1.0

      Range
      42267417..42551842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038653376.1 → XP_038509304.1  estrogen receptor isoform X2

      UniProtKB/TrEMBL
      A0A8C0KS07
      Conserved Domains (3) summary
      cd07171
      Location:181 → 264
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:40 → 182
      Oest_recep; Oestrogen receptor
      cl11397
      Location:313 → 463
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    2. XM_038653375.1 → XP_038509303.1  estrogen receptor isoform X1

      UniProtKB/TrEMBL
      A0A8C0KQE4, A0A8C0SV34, A0A8I3MAV6
      Conserved Domains (4) summary
      cd06949
      Location:313 → 550
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:181 → 264
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:40 → 182
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:559 → 598
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049261.1 Alternate UMICH_Zoey_3.1

      Range
      42140418..42417150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

      Range
      41990600..42280338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

      Range
      42491321..42775607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      42923315..43207109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials