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    TIMP2 TIMP metallopeptidase inhibitor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 403633, updated on 19-Jun-2024

    Summary

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    Gene symbol
    TIMP2
    Gene description
    TIMP metallopeptidase inhibitor 2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See TIMP2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (3140666..3188540)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (3146850..3191997) , (3159531..3168419)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (3369678..3414817)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (3162992..3208134) , (3175669..3184556)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (3288768..3333886) , (3301440..3310326)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102153844 Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene ubiquitin specific peptidase 36 Neighboring gene cytohesin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryoplasty for Canine Iliac Artery Stenosis and its Impact on Expression of TIMP-2 and MMP-2. Wu Z, et al. Vasc Endovascular Surg, 2015 Jul-Aug. PMID 26335992
    2. The cloning and expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase 2 in normal canine lymph nodes and in canine lymphoma. Newman RG, et al. Res Vet Sci, 2008 Apr. PMID 17604063
    3. Dynamic alterations of connexin43, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 during ventricular fibrillation in canine. Wang J, et al. Mol Cell Biochem, 2014 Jun. PMID 24639125
    4. Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases and vascular endothelial growth factor in canine mast cell tumours. Giantin M, et al. J Comp Pathol, 2012 Nov. PMID 22520817
    5. Cloning of canine IL-1ra, TNFR and TIMP-2. Campbell SE, et al. Vet Immunol Immunopathol, 2001 Jan 26. PMID 11182158

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest cryoplasty increases the expression of TIMP-2 and decreases the expression of MMP-2, thereby inhibiting vascular hyperplasia and collagen fibers synthesis in the stenotic vessels.
      Title: Cryoplasty for Canine Iliac Artery Stenosis and its Impact on Expression of TIMP-2 and MMP-2.
    2. the alteration of Cx43 and/or phosphorylated Cx43 levels and the imbalance of MMP-2 and TIMP-2 may contribute to the initiation and/or persistence of ventricular fibrillation.
      Title: Dynamic alterations of connexin43, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 during ventricular fibrillation in canine.
    3. This study demonstrates that MMP-9, TIMP-2 and VEGF-A expression is related to histological grade in canine mast cell tumors.
      Title: Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases and vascular endothelial growth factor in canine mast cell tumours.
    4. Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10.
      Title: Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells.
    5. The cloning of matrix metallopeptidase 2 (MMP2)and its expression with tissue inhibitor of matrix metalloproteinase 2 (TIMP2) in canine lymph nodes and lymphomas are reported.
      Title: The cloning and expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase 2 in normal canine lymph nodes and in canine lymphoma.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metalloproteinase inhibitor 2; LOW QUALITY PROTEIN: metalloproteinase inhibitor 2
    Names
    TIMP-2
    tissue inhibitor of matrix metalloproteinase-2
    tissue inhibitor of metalloproteinase-2
    tissue inhibitor of metalloproteinases 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003082.1 → NP_001003082.1  metalloproteinase inhibitor 2 precursor

      See identical proteins and their annotated locations for NP_001003082.1

      Status: PROVISIONAL

      Source sequence(s)
      AF112115
      UniProtKB/Swiss-Prot
      O77804, Q9TTE9, Q9TTY1
      UniProtKB/TrEMBL
      A0A8C0K5I4
      Conserved Domains (1) summary
      cd03585
      Location:27 → 209
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      3140666..3188540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038674948.1 → XP_038530876.1  metalloproteinase inhibitor 2 isoform X3

      Conserved Domains (1) summary
      cd03585
      Location:14 → 179
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    2. XM_038674947.1 → XP_038530875.1  metalloproteinase inhibitor 2 isoform X2

      Conserved Domains (1) summary
      cd03585
      Location:48 → 214
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    3. XM_038674949.1 → XP_038530877.1  metalloproteinase inhibitor 2 isoform X4

      Conserved Domains (1) summary
      cd03585
      Location:2 → 166
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    4. XM_038674945.1 → XP_038530873.1  metalloproteinase inhibitor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RBM2

    5. XM_038674944.1 → XP_038530872.1  metalloproteinase inhibitor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RBM2

    6. XM_038674946.1 → XP_038530874.1  metalloproteinase inhibitor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RBM2

    7. XM_038674950.1 → XP_038530878.1  metalloproteinase inhibitor 2 isoform X5

      Conserved Domains (1) summary
      cd03585
      Location:2 → 166
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    8. XM_038674951.1 → XP_038530879.1  metalloproteinase inhibitor 2 isoform X5

      Conserved Domains (1) summary
      cd03585
      Location:2 → 166
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      3162992..3208134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      3175669..3184556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      3288768..3333886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      3301440..3310326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      3369678..3414817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      3146850..3191997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      3159531..3168419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TTY1.2 GenPept UniProtKB/Swiss-Prot:Q9TTY1

    Gene LinkOut

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